A Piperazine Linked Rhodamine-BODIPY FRET-based Fluorescent Sensor for Highly Selective Pd2+ and Biothiol Detection

Fung-Kit Tang, Yanyan Chen, Daniel Nnaemaka Tritton, Zongwei Cai, Ken Cham-Fai Leung*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

2 Citations (Scopus)

Abstract

A class of rhodamine-based fluorescent sensors for the selective and sensitive detection of Pd2+ metal ions in aqueous media has been developed. A rhodamine-based sensor PMS and a rhodamine-BODIPY Förster resonance energy transfer (FRET)-pair sensor PRS have been incorporated with a piperazine linker and an O−N−S−N podand ligand for specific recognition of Pd2+ ion. Both probes displayed colorimetric and fluorescent ratiometric changes when exposed to Pd2+, due to their spirolactam rings opening and restoring rhodamine conjugation. PRS is highly selective to Pd2+ over 22 other metal ions, showing a 0.6-fold ratiometric difference at I600nm/I515nm. Additionally, the lactam ring in Pd2+ coordinated PRS-Pd could be switched back to the closed form in the presence of various thiols, providing a “red-green traffic light” detection mechanism between red and green emission. Furthermore, PRS showed excellent cell viability and was successfully employed to image Pd2+ and the PRS-Pd complex ensemble could interchangeably detect biothiols including glutathione (GSH) in A549 human lung cancer cells.
Original languageEnglish
Article numbere202300477
Number of pages7
JournalChemistry - An Asian Journal
Volume18
Issue number16
Early online date30 Jun 2023
DOIs
Publication statusPublished - 15 Aug 2023

Scopus Subject Areas

  • Chemistry(all)
  • Biochemistry
  • Organic Chemistry

User-Defined Keywords

  • BODIPY
  • FRET
  • Palladium
  • Rhodamine
  • Fluorescence

Fingerprint

Dive into the research topics of 'A Piperazine Linked Rhodamine-BODIPY FRET-based Fluorescent Sensor for Highly Selective Pd2+ and Biothiol Detection'. Together they form a unique fingerprint.

Cite this