@article{8f5c4abfb0e54f1d836463a9313a2847,
title = "A parallel G-quadruplex-selective luminescent probe for the detection of nanomolar calcium(II) ion",
abstract = "A parallel G-quadruplex-selective iridium(III) complex has been synthesized and employed as a luminescent probe in a label-free G-quadruplex-based detection assay for Ca2+ ions in aqueous solution. In this assay, a guanine-rich oligonucleotide (G4, 5'-G4T4G4-3') initially exists in an antiparallel G-quadruplex conformation, resulting in a low luminescence signal. Upon incubation with Ca2+ ions, the antiparallel G-quadruplex is induced into a parallel G-quadruplex conformation, which greatly enhances the luminescence emission of the iridium(III) probe. This method was highly sensitive for Ca2+ ions with a limit of detection in the nanomolar range, and was selective for Ca2+ over other metal ions.",
keywords = "G-quadruplex, Iridium, Luminescence, Metal complex",
author = "He, {Hong Zhang} and Modi Wang and Chan, {Daniel Shiu Hin} and Leung, {Chung Hang} and Xuexia Lin and Lin, {Jin Ming} and Ma, {Dik Lung}",
note = "Funding Information: This work is supported by Hong Kong Baptist University ( FRG2/11-12/009 and FRG2/12-13/021 ), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/11101212), the Research Grants Council (HKBU/201811, HKBU/204612 and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), the Science and Technology Development Fund, Macao SAR (001/2012/A) and the University of Macau (MYRG091(Y2-L2)-ICMS12-LCH and MYRG121(Y2-L2)-ICMS12-LCH). ",
year = "2013",
month = dec,
day = "15",
doi = "10.1016/j.ymeth.2013.07.021",
language = "English",
volume = "64",
pages = "212--217",
journal = "Methods",
issn = "1046-2023",
publisher = "Academic Press Inc.",
number = "3",
}