A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

Quan-Bin Han; Ling Yang; Yu-Lin Wang; Chun-Feng Qiao; Jing-Zheng Song; Han-Dong Sun; Hong-Xi Xu

doi:10.1002/cbdv.200690000

A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

Quan-Bin Han
, Ling Yang
, Yu-Lin Wang
, Chun-Feng Qiao
, Jing-Zheng Song
, Han-Dong Sun
, Hong-Xi Xu

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

46 Citations (Scopus)

Abstract

Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).

Original language	English
Pages (from-to)	101-105
Journal	Chemistry and Biodiversity
Volume	3
Issue number	1
DOIs	https://doi.org/10.1002/cbdv.200690000
Publication status	Published - Jan 2006

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10.1002/cbdv.200690000

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abstract = "Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).",

author = "Quan-Bin Han and Ling Yang and Yu-Lin Wang and Chun-Feng Qiao and Jing-Zheng Song and Han-Dong Sun and Hong-Xi Xu",

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AU - Han, Quan-Bin

AU - Yang, Ling

AU - Wang, Yu-Lin

AU - Qiao, Chun-Feng

AU - Song, Jing-Zheng

AU - Sun, Han-Dong

AU - Xu, Hong-Xi

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N2 - Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).

AB - Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).

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U2 - 10.1002/cbdv.200690000

DO - 10.1002/cbdv.200690000

M3 - Journal article

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VL - 3

SP - 101

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JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

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ER -

A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

Abstract

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