A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

Quan-Bin Han; Ling Yang; Yu-Lin Wang; Chun-Feng Qiao; Jing-Zheng Song; Han-Dong Sun; Hong-Xi Xu

doi:10.1002/cbdv.200690000

A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

Quan-Bin Han, Ling Yang, Yu-Lin Wang, Chun-Feng Qiao, Jing-Zheng Song, Han-Dong Sun, Hong-Xi Xu

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

45 Citations (Scopus)

Abstract

Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).

Original language	English
Pages (from-to)	101-105
Journal	Chemistry and Biodiversity
Volume	3
Issue number	1
DOIs	https://doi.org/10.1002/cbdv.200690000
Publication status	Published - Jan 2006

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abstract = "Two new polyprenylated xanthone epimers were isolated from gamboges of Garcinia hanburyi, and identified by detailed spectroscopic analysis as 30-hydroxygambogic acid (2a) and its (2S)-epimer 30-hydroxyepigambogic acid (2b). Both compounds exhibited significant cytotoxicities against the human leukemia K562/S and the corresponding doxorubicin-resistant K562/R cell lines (Table 2).",

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AU - Song, Jing-Zheng

AU - Sun, Han-Dong

AU - Xu, Hong-Xi

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A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges

Abstract

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