A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation

Sharon Lai Fung Chan; Lihua Lu; Tsz Lung Lam; Siu Cheong Yan; Chung Hang Leung; Dik Lung Ma

doi:10.2174/1567205012666150504150726

A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation

Sharon Lai Fung Chan^*, Lihua Lu, Tsz Lung Lam, Siu Cheong Yan, Chung Hang Leung, Dik Lung Ma

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

19 Citations (Scopus)

Abstract

We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO₄ 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.

Original language	English
Pages (from-to)	434-438
Number of pages	5
Journal	Current Alzheimer Research
Volume	12
Issue number	5
DOIs	https://doi.org/10.2174/1567205012666150504150726
Publication status	Published - 2015

Scopus Subject Areas

Neurology
Clinical Neurology

User-Defined Keywords

2-acetylbenzo[b]thiophen-3-olate
Alzheimer's disease
Beta-amyloid
Ruthenium(II)
Tris(2-pyridylmethyl)amine

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10.2174/1567205012666150504150726

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title = "A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation",

abstract = "We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO4 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.",

keywords = "2-acetylbenzo[b]thiophen-3-olate, Alzheimer's disease, Beta-amyloid, Ruthenium(II), Tris(2-pyridylmethyl)amine",

author = "Chan, {Sharon Lai Fung} and Lihua Lu and Lam, {Tsz Lung} and Yan, {Siu Cheong} and Leung, {Chung Hang} and Ma, {Dik Lung}",

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year = "2015",

doi = "10.2174/1567205012666150504150726",

language = "English",

volume = "12",

pages = "434--438",

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T1 - A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation

AU - Chan, Sharon Lai Fung

AU - Lu, Lihua

AU - Lam, Tsz Lung

AU - Yan, Siu Cheong

AU - Leung, Chung Hang

AU - Ma, Dik Lung

PY - 2015

Y1 - 2015

N2 - We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO4 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.

AB - We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO4 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.

KW - 2-acetylbenzo[b]thiophen-3-olate

KW - Alzheimer's disease

KW - Beta-amyloid

KW - Ruthenium(II)

KW - Tris(2-pyridylmethyl)amine

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DO - 10.2174/1567205012666150504150726

M3 - Journal article

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AN - SCOPUS:84930911730

SN - 1567-2050

VL - 12

SP - 434

EP - 438

JO - Current Alzheimer Research

JF - Current Alzheimer Research

IS - 5

ER -

A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation

Abstract

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