A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation

Sharon Lai Fung Chan*, Lihua Lu, Tsz Lung Lam, Siu Cheong Yan, Chung Hang Leung, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

We report herein the synthesis and application of a novel tetradentate ruthenium(II) complex 1 containing a tris(2-pyridylmethyl)amine (tpa) ligand as an inhibitor of β-amyloid fibrillogenesis. [Ru(tpa)(bt)]ClO4 1 (bt =2-acetylbenzo[b]thiophene-3-olate) showed significant inhibition of Aβ(1-40) peptide aggregation in vitro, which was confirmed by a Thioflavin T assay and transmission electron microscopy imaging.

Original languageEnglish
Pages (from-to)434-438
Number of pages5
JournalCurrent Alzheimer Research
Volume12
Issue number5
DOIs
Publication statusPublished - 2015

Scopus Subject Areas

  • Neurology
  • Clinical Neurology

User-Defined Keywords

  • 2-acetylbenzo[b]thiophen-3-olate
  • Alzheimer's disease
  • Beta-amyloid
  • Ruthenium(II)
  • Tris(2-pyridylmethyl)amine

Fingerprint

Dive into the research topics of 'A novel tetradentate ruthenium(II) complex containing tris(2- pyridylmethyl)amine (tpa) as an Inhibitor of Beta-Amyloid Fibrillation'. Together they form a unique fingerprint.

Cite this