A novel ratiometric emission probe for Ca2+ in living cells

Qiaoling Liu; Wei Bian; Heping Shi; Li Fan; Shaomin Shuang; Chuan Dong; Martin M.F. Choi

doi:10.1039/c2ob26888d

A novel ratiometric emission probe for Ca²⁺ in living cells

Qiaoling Liu
, Wei Bian
, Heping Shi
, Li Fan
, Shaomin Shuang
, Chuan Dong^*
, Martin M.F. Choi

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

14 Citations (Scopus)

Abstract

A ratiometric fluorescent probe for Ca²⁺ based on 1,3,4-oxadiazole derivative has been designed and developed. The probe exhibits a large Stokes shift of 202 nm and a highly selective ratiometric emission response (490/582 nm) to Ca²⁺ over other metal cations. Additionally, the probe can readily reveal the changes of intracellular Ca²⁺ concentration in living human umbilical vein endothelial cells.

Original language	English
Pages (from-to)	503-508
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	11
Issue number	3
DOIs	https://doi.org/10.1039/c2ob26888d
Publication status	Published - 21 Jan 2013

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title = "A novel ratiometric emission probe for Ca2+ in living cells",

abstract = "A ratiometric fluorescent probe for Ca2+ based on 1,3,4-oxadiazole derivative has been designed and developed. The probe exhibits a large Stokes shift of 202 nm and a highly selective ratiometric emission response (490/582 nm) to Ca2+ over other metal cations. Additionally, the probe can readily reveal the changes of intracellular Ca2+ concentration in living human umbilical vein endothelial cells.",

author = "Qiaoling Liu and Wei Bian and Heping Shi and Li Fan and Shaomin Shuang and Chuan Dong and Choi, \{Martin M.F.\}",

note = "This work was supported by grants from the National Natural Science Foundation of China (21175086 and 21175087), and the Hundred Talent Programme of Shanxi Province, Shanxi International S\&T Cooperation Program of China (2011081017).",

year = "2013",

month = jan,

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doi = "10.1039/c2ob26888d",

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TY - JOUR

T1 - A novel ratiometric emission probe for Ca2+ in living cells

AU - Liu, Qiaoling

AU - Bian, Wei

AU - Shi, Heping

AU - Fan, Li

AU - Shuang, Shaomin

AU - Dong, Chuan

AU - Choi, Martin M.F.

N1 - This work was supported by grants from the National Natural Science Foundation of China (21175086 and 21175087), and the Hundred Talent Programme of Shanxi Province, Shanxi International S&T Cooperation Program of China (2011081017).

PY - 2013/1/21

Y1 - 2013/1/21

N2 - A ratiometric fluorescent probe for Ca2+ based on 1,3,4-oxadiazole derivative has been designed and developed. The probe exhibits a large Stokes shift of 202 nm and a highly selective ratiometric emission response (490/582 nm) to Ca2+ over other metal cations. Additionally, the probe can readily reveal the changes of intracellular Ca2+ concentration in living human umbilical vein endothelial cells.

AB - A ratiometric fluorescent probe for Ca2+ based on 1,3,4-oxadiazole derivative has been designed and developed. The probe exhibits a large Stokes shift of 202 nm and a highly selective ratiometric emission response (490/582 nm) to Ca2+ over other metal cations. Additionally, the probe can readily reveal the changes of intracellular Ca2+ concentration in living human umbilical vein endothelial cells.

UR - https://www.scopus.com/pages/publications/84871089663

U2 - 10.1039/c2ob26888d

DO - 10.1039/c2ob26888d

M3 - Journal article

C2 - 23202385

AN - SCOPUS:84871089663

SN - 1477-0520

VL - 11

SP - 503

EP - 508

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 3

ER -

A novel ratiometric emission probe for Ca²⁺ in living cells

Abstract

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