A novel ratiometric emission probe for Ca2+ in living cells

Qiaoling Liu, Wei Bian, Heping Shi, Li Fan, Shaomin Shuang, Chuan Dong*, Martin M F CHOI

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

12 Citations (Scopus)


A ratiometric fluorescent probe for Ca2+ based on 1,3,4-oxadiazole derivative has been designed and developed. The probe exhibits a large Stokes shift of 202 nm and a highly selective ratiometric emission response (490/582 nm) to Ca2+ over other metal cations. Additionally, the probe can readily reveal the changes of intracellular Ca2+ concentration in living human umbilical vein endothelial cells.

Original languageEnglish
Pages (from-to)503-508
Number of pages6
JournalOrganic and Biomolecular Chemistry
Issue number3
Publication statusPublished - 21 Jan 2013

Scopus Subject Areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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