A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome

S. C. W. Sze, Y. Tong*, Y. B. Zhang, Z. J. Zhang, A. S. L. Lau, H. K. Wong, K. W. Tsang, T. B. Ng

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

34 Citations (Scopus)


Ethnopharmacological relevance
Many clinical and experimental reports demonstrated that Erxian Decoction (EXD) was effective in relieving menopausal syndrome.

Aim of the study
The mechanisms of action of EXD were explored on the endocrine and antioxidant regimen.

Materials and methods
Menopause causes a decline in both endocrine function and activities of antioxidant enzymes. In this study, 12-month-old female Sprague–Dawley-rats (SD-rats) with a low serum estradiol level were employed. Their endocrine functions after treatment with EXD were assessed by the determination of their serum estradiol level and ovarian mRNA levels of aromatase, which is a key enzyme for biosynthesis of estradiol. Meanwhile, superoxide dismutase-1 (SOD), catalase (CAT) and glutathione peroxidase (GPx-1) in the liver were also determined to assess the effect of EXD on the antioxidant regimen.

Results revealed a significant elevation in serum estradiol level and the mRNA level of ovarian aromatase and liver CAT in the EXD-treated menopausal rat model.

The results obtained from mRNA and estradiol level of the present investigation revealed that the EXD relieves the menopausal syndrome involved an increase of endocrine and antioxidant function through, at least, the activation of aromatase and CAT detoxifying pathways.
Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalJournal of Ethnopharmacology
Issue number1
Publication statusPublished - 4 May 2009
Externally publishedYes

User-Defined Keywords

  • Antioxidant
  • Chinese medicine
  • Endocrine function
  • Erxian Decoction
  • Menopause


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