A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome

S. C. W. Sze; Y. Tong; Y. B. Zhang; Z. J. Zhang; A. S. L. Lau; H. K. Wong; K. W. Tsang; T. B. Ng

doi:10.1016/j.jep.2009.02.034

A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome

S. C. W. Sze, Y. Tong^*, Y. B. Zhang, Z. J. Zhang, A. S. L. Lau, H. K. Wong, K. W. Tsang, T. B. Ng

^*Corresponding author for this work

Golden Meditech Centre for NeuroRegeneration Sciences

Research output: Contribution to journal › Journal article › peer-review

34 Citations (Scopus)

Abstract

Ethnopharmacological relevance
Many clinical and experimental reports demonstrated that Erxian Decoction (EXD) was effective in relieving menopausal syndrome.

Aim of the study
The mechanisms of action of EXD were explored on the endocrine and antioxidant regimen.

Materials and methods
Menopause causes a decline in both endocrine function and activities of antioxidant enzymes. In this study, 12-month-old female Sprague–Dawley-rats (SD-rats) with a low serum estradiol level were employed. Their endocrine functions after treatment with EXD were assessed by the determination of their serum estradiol level and ovarian mRNA levels of aromatase, which is a key enzyme for biosynthesis of estradiol. Meanwhile, superoxide dismutase-1 (SOD), catalase (CAT) and glutathione peroxidase (GPx-1) in the liver were also determined to assess the effect of EXD on the antioxidant regimen.

Results
Results revealed a significant elevation in serum estradiol level and the mRNA level of ovarian aromatase and liver CAT in the EXD-treated menopausal rat model.

Conclusions
The results obtained from mRNA and estradiol level of the present investigation revealed that the EXD relieves the menopausal syndrome involved an increase of endocrine and antioxidant function through, at least, the activation of aromatase and CAT detoxifying pathways.

Original language	English
Pages (from-to)	27-33
Number of pages	7
Journal	Journal of Ethnopharmacology
Volume	123
Issue number	1
DOIs	https://doi.org/10.1016/j.jep.2009.02.034
Publication status	Published - 4 May 2009

User-Defined Keywords

Antioxidant
Chinese medicine
Endocrine function
Erxian Decoction
Menopause

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10.1016/j.jep.2009.02.034

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title = "A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome",

abstract = "Ethnopharmacological relevanceMany clinical and experimental reports demonstrated that Erxian Decoction (EXD) was effective in relieving menopausal syndrome.Aim of the studyThe mechanisms of action of EXD were explored on the endocrine and antioxidant regimen.Materials and methodsMenopause causes a decline in both endocrine function and activities of antioxidant enzymes. In this study, 12-month-old female Sprague–Dawley-rats (SD-rats) with a low serum estradiol level were employed. Their endocrine functions after treatment with EXD were assessed by the determination of their serum estradiol level and ovarian mRNA levels of aromatase, which is a key enzyme for biosynthesis of estradiol. Meanwhile, superoxide dismutase-1 (SOD), catalase (CAT) and glutathione peroxidase (GPx-1) in the liver were also determined to assess the effect of EXD on the antioxidant regimen.ResultsResults revealed a significant elevation in serum estradiol level and the mRNA level of ovarian aromatase and liver CAT in the EXD-treated menopausal rat model.ConclusionsThe results obtained from mRNA and estradiol level of the present investigation revealed that the EXD relieves the menopausal syndrome involved an increase of endocrine and antioxidant function through, at least, the activation of aromatase and CAT detoxifying pathways.",

keywords = "Antioxidant, Chinese medicine, Endocrine function, Erxian Decoction, Menopause",

author = "Sze, {S. C. W.} and Y. Tong and Zhang, {Y. B.} and Zhang, {Z. J.} and Lau, {A. S. L.} and Wong, {H. K.} and Tsang, {K. W.} and Ng, {T. B.}",

note = "Funding information: This research was supported in part by a grant from Small Project Funding (no. 200607176131), Seed Funding Programme for Applied Research (no. 200802160025), the University of Hong Kong and Liu Hao Tsing Foundation Ltd. We also thank Ms. Cindy Lee for expert technical assistance. Publisher copyright: {\textcopyright} 2009 Elsevier Ireland Ltd. All rights reserved.",

year = "2009",

month = may,

day = "4",

doi = "10.1016/j.jep.2009.02.034",

language = "English",

volume = "123",

pages = "27--33",

journal = "Journal of Ethnopharmacology",

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T1 - A novel mechanism

T2 - Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome

AU - Sze, S. C. W.

AU - Tong, Y.

AU - Zhang, Y. B.

AU - Zhang, Z. J.

AU - Lau, A. S. L.

AU - Wong, H. K.

AU - Tsang, K. W.

AU - Ng, T. B.

N1 - Funding information: This research was supported in part by a grant from Small Project Funding (no. 200607176131), Seed Funding Programme for Applied Research (no. 200802160025), the University of Hong Kong and Liu Hao Tsing Foundation Ltd. We also thank Ms. Cindy Lee for expert technical assistance. Publisher copyright: © 2009 Elsevier Ireland Ltd. All rights reserved.

PY - 2009/5/4

Y1 - 2009/5/4

N2 - Ethnopharmacological relevanceMany clinical and experimental reports demonstrated that Erxian Decoction (EXD) was effective in relieving menopausal syndrome.Aim of the studyThe mechanisms of action of EXD were explored on the endocrine and antioxidant regimen.Materials and methodsMenopause causes a decline in both endocrine function and activities of antioxidant enzymes. In this study, 12-month-old female Sprague–Dawley-rats (SD-rats) with a low serum estradiol level were employed. Their endocrine functions after treatment with EXD were assessed by the determination of their serum estradiol level and ovarian mRNA levels of aromatase, which is a key enzyme for biosynthesis of estradiol. Meanwhile, superoxide dismutase-1 (SOD), catalase (CAT) and glutathione peroxidase (GPx-1) in the liver were also determined to assess the effect of EXD on the antioxidant regimen.ResultsResults revealed a significant elevation in serum estradiol level and the mRNA level of ovarian aromatase and liver CAT in the EXD-treated menopausal rat model.ConclusionsThe results obtained from mRNA and estradiol level of the present investigation revealed that the EXD relieves the menopausal syndrome involved an increase of endocrine and antioxidant function through, at least, the activation of aromatase and CAT detoxifying pathways.

AB - Ethnopharmacological relevanceMany clinical and experimental reports demonstrated that Erxian Decoction (EXD) was effective in relieving menopausal syndrome.Aim of the studyThe mechanisms of action of EXD were explored on the endocrine and antioxidant regimen.Materials and methodsMenopause causes a decline in both endocrine function and activities of antioxidant enzymes. In this study, 12-month-old female Sprague–Dawley-rats (SD-rats) with a low serum estradiol level were employed. Their endocrine functions after treatment with EXD were assessed by the determination of their serum estradiol level and ovarian mRNA levels of aromatase, which is a key enzyme for biosynthesis of estradiol. Meanwhile, superoxide dismutase-1 (SOD), catalase (CAT) and glutathione peroxidase (GPx-1) in the liver were also determined to assess the effect of EXD on the antioxidant regimen.ResultsResults revealed a significant elevation in serum estradiol level and the mRNA level of ovarian aromatase and liver CAT in the EXD-treated menopausal rat model.ConclusionsThe results obtained from mRNA and estradiol level of the present investigation revealed that the EXD relieves the menopausal syndrome involved an increase of endocrine and antioxidant function through, at least, the activation of aromatase and CAT detoxifying pathways.

KW - Antioxidant

KW - Chinese medicine

KW - Endocrine function

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DO - 10.1016/j.jep.2009.02.034

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JO - Journal of Ethnopharmacology

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A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome

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