A novel green gelatin-agar microencapsulation system with P. urinaria as an improved anti-A. niger model

Pik Ling Lam; Stanton Hon Lung Kok; Yiu Wah Ho; Raymond Siu Ming Wong; Gregory Yin Ming Cheng; Chor Hing Cheng; Kim Hung Lam; Roberto Gambari; Kenneth Ka Ho Lee; Chung Hin CHUI

doi:10.1016/j.carbpol.2012.09.080

A novel green gelatin-agar microencapsulation system with P. urinaria as an improved anti-A. niger model

Pik Ling Lam, Stanton Hon Lung Kok, Yiu Wah Ho, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Chor Hing Cheng, Kim Hung Lam, Roberto Gambari^*, Kenneth Ka Ho Lee, Chung Hin CHUI

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

19 Citations (Scopus)

Abstract

In this study, a novel green microencapsulation system was used to develop Phyllanthus urinaria (PU) extract containing microcapsules. Agar was used with gelatin as the wall matrix materials of microcapsules to prevent the use of toxic crosslinker formaldehyde. Microencapsulated PU extract was developed to improve the potential antifungal activities of PU water extracts. The active components and surface morphology of PU extract containing microcapsules were analyzed by liquid chromatography/mass spectrometry and scanning electron microscopy, respectively. The in vitro release study demonstrated that approximately 80% of drug was released after 120 h. PU loaded microcapsules were shown to have a stronger anti-Aspergillus niger activity than the free drug.

Original language	English
Pages (from-to)	877-880
Number of pages	4
Journal	Carbohydrate Polymers
Volume	92
Issue number	1
DOIs	https://doi.org/10.1016/j.carbpol.2012.09.080
Publication status	Published - 30 Jan 2013

Scopus Subject Areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

User-Defined Keywords

Agar
Aspergillus niger
Gelatin
Microcapsules
Phyllanthus urinaria

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10.1016/j.carbpol.2012.09.080

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@article{1735b04031494520b00b996e2ba721cc,

title = "A novel green gelatin-agar microencapsulation system with P. urinaria as an improved anti-A. niger model",

abstract = "In this study, a novel green microencapsulation system was used to develop Phyllanthus urinaria (PU) extract containing microcapsules. Agar was used with gelatin as the wall matrix materials of microcapsules to prevent the use of toxic crosslinker formaldehyde. Microencapsulated PU extract was developed to improve the potential antifungal activities of PU water extracts. The active components and surface morphology of PU extract containing microcapsules were analyzed by liquid chromatography/mass spectrometry and scanning electron microscopy, respectively. The in vitro release study demonstrated that approximately 80% of drug was released after 120 h. PU loaded microcapsules were shown to have a stronger anti-Aspergillus niger activity than the free drug.",

keywords = "Agar, Aspergillus niger, Gelatin, Microcapsules, Phyllanthus urinaria",

author = "Lam, {Pik Ling} and Kok, {Stanton Hon Lung} and Ho, {Yiu Wah} and Wong, {Raymond Siu Ming} and Cheng, {Gregory Yin Ming} and Cheng, {Chor Hing} and Lam, {Kim Hung} and Roberto Gambari and Lee, {Kenneth Ka Ho} and CHUI, {Chung Hin}",

note = "Funding Information: We would like to acknowledge the support from Haematology Research Fund, PWH, CUHK .",

year = "2013",

month = jan,

day = "30",

doi = "10.1016/j.carbpol.2012.09.080",

language = "English",

volume = "92",

pages = "877--880",

journal = "Carbohydrate Polymers",

issn = "0144-8617",

publisher = "Elsevier Ltd.",

number = "1",

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TY - JOUR

T1 - A novel green gelatin-agar microencapsulation system with P. urinaria as an improved anti-A. niger model

AU - Lam, Pik Ling

AU - Kok, Stanton Hon Lung

AU - Ho, Yiu Wah

AU - Wong, Raymond Siu Ming

AU - Cheng, Gregory Yin Ming

AU - Cheng, Chor Hing

AU - Lam, Kim Hung

AU - Gambari, Roberto

AU - Lee, Kenneth Ka Ho

AU - CHUI, Chung Hin

N1 - Funding Information: We would like to acknowledge the support from Haematology Research Fund, PWH, CUHK .

PY - 2013/1/30

Y1 - 2013/1/30

N2 - In this study, a novel green microencapsulation system was used to develop Phyllanthus urinaria (PU) extract containing microcapsules. Agar was used with gelatin as the wall matrix materials of microcapsules to prevent the use of toxic crosslinker formaldehyde. Microencapsulated PU extract was developed to improve the potential antifungal activities of PU water extracts. The active components and surface morphology of PU extract containing microcapsules were analyzed by liquid chromatography/mass spectrometry and scanning electron microscopy, respectively. The in vitro release study demonstrated that approximately 80% of drug was released after 120 h. PU loaded microcapsules were shown to have a stronger anti-Aspergillus niger activity than the free drug.

AB - In this study, a novel green microencapsulation system was used to develop Phyllanthus urinaria (PU) extract containing microcapsules. Agar was used with gelatin as the wall matrix materials of microcapsules to prevent the use of toxic crosslinker formaldehyde. Microencapsulated PU extract was developed to improve the potential antifungal activities of PU water extracts. The active components and surface morphology of PU extract containing microcapsules were analyzed by liquid chromatography/mass spectrometry and scanning electron microscopy, respectively. The in vitro release study demonstrated that approximately 80% of drug was released after 120 h. PU loaded microcapsules were shown to have a stronger anti-Aspergillus niger activity than the free drug.

KW - Agar

KW - Aspergillus niger

KW - Gelatin

KW - Microcapsules

KW - Phyllanthus urinaria

UR - http://www.scopus.com/inward/record.url?scp=84868256841&partnerID=8YFLogxK

U2 - 10.1016/j.carbpol.2012.09.080

DO - 10.1016/j.carbpol.2012.09.080

M3 - Journal article

C2 - 23218379

AN - SCOPUS:84868256841

SN - 0144-8617

VL - 92

SP - 877

EP - 880

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

IS - 1

ER -

A novel green gelatin-agar microencapsulation system with P. urinaria as an improved anti-A. niger model

Abstract

Scopus Subject Areas

User-Defined Keywords

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