A novel fluorescent probe for sensing and imaging extreme acidity

Weifen Niu; Li Fan; Ming Nan; Man Shing Wong; Shaomin Shuang; Chuan Dong

doi:10.1016/j.snb.2016.04.084

A novel fluorescent probe for sensing and imaging extreme acidity

Weifen Niu, Li Fan, Ming Nan, Man Shing Wong, Shaomin Shuang, Chuan Dong^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

14 Citations (Scopus)

Abstract

A novel fluorescent probe for extreme acidity is developed using biocompatible indole derivative as the fluorophore. The probe is linearly proportional to extreme acidity range of 2.3-3.6 with pK_a 2.89. Moreover, it displays promising spectroscopic features such as large Stokes shift (145 nm), highly selective response to H⁺ over various metal ions, good photostability and excellent reversibility. The confocal laser scanning microscope images display the probe possesses excellent cell membrane permeability, and is further applied successfully to monitor pH fluctuations of extreme acidity range in E. coli cells without influence of autofluorescence and native cellular species in biological systems.

Original language	English
Pages (from-to)	534-540
Number of pages	7
Journal	Sensors and Actuators B: Chemical
Volume	234
DOIs	https://doi.org/10.1016/j.snb.2016.04.084
Publication status	Published - 29 Oct 2016

Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

User-Defined Keywords

Extreme acidity
Fluorescent probe
Imaging
pH

Access to Document

10.1016/j.snb.2016.04.084

Cite this

@article{e4a4aaaab7bf4bc7b5be75081033af7a,

title = "A novel fluorescent probe for sensing and imaging extreme acidity",

abstract = "A novel fluorescent probe for extreme acidity is developed using biocompatible indole derivative as the fluorophore. The probe is linearly proportional to extreme acidity range of 2.3-3.6 with pKa 2.89. Moreover, it displays promising spectroscopic features such as large Stokes shift (145 nm), highly selective response to H+ over various metal ions, good photostability and excellent reversibility. The confocal laser scanning microscope images display the probe possesses excellent cell membrane permeability, and is further applied successfully to monitor pH fluctuations of extreme acidity range in E. coli cells without influence of autofluorescence and native cellular species in biological systems.",

keywords = "Extreme acidity, Fluorescent probe, Imaging, pH",

author = "Weifen Niu and Li Fan and Ming Nan and Wong, {Man Shing} and Shaomin Shuang and Chuan Dong",

note = "Funding Information: This work was supported by the National Natural Science Foundation of China (No. 21475080 and No. 21575084 ), the Hundred Talent Program of Shanxi Province and Shanxi Province Scholarship Council of China . ",

year = "2016",

month = oct,

day = "29",

doi = "10.1016/j.snb.2016.04.084",

language = "English",

volume = "234",

pages = "534--540",

journal = "Sensors and Actuators B: Chemical",

issn = "0925-4005",

publisher = "Elsevier",

}

TY - JOUR

T1 - A novel fluorescent probe for sensing and imaging extreme acidity

AU - Niu, Weifen

AU - Fan, Li

AU - Nan, Ming

AU - Wong, Man Shing

AU - Shuang, Shaomin

AU - Dong, Chuan

N1 - Funding Information: This work was supported by the National Natural Science Foundation of China (No. 21475080 and No. 21575084 ), the Hundred Talent Program of Shanxi Province and Shanxi Province Scholarship Council of China .

PY - 2016/10/29

Y1 - 2016/10/29

N2 - A novel fluorescent probe for extreme acidity is developed using biocompatible indole derivative as the fluorophore. The probe is linearly proportional to extreme acidity range of 2.3-3.6 with pKa 2.89. Moreover, it displays promising spectroscopic features such as large Stokes shift (145 nm), highly selective response to H+ over various metal ions, good photostability and excellent reversibility. The confocal laser scanning microscope images display the probe possesses excellent cell membrane permeability, and is further applied successfully to monitor pH fluctuations of extreme acidity range in E. coli cells without influence of autofluorescence and native cellular species in biological systems.

AB - A novel fluorescent probe for extreme acidity is developed using biocompatible indole derivative as the fluorophore. The probe is linearly proportional to extreme acidity range of 2.3-3.6 with pKa 2.89. Moreover, it displays promising spectroscopic features such as large Stokes shift (145 nm), highly selective response to H+ over various metal ions, good photostability and excellent reversibility. The confocal laser scanning microscope images display the probe possesses excellent cell membrane permeability, and is further applied successfully to monitor pH fluctuations of extreme acidity range in E. coli cells without influence of autofluorescence and native cellular species in biological systems.

KW - Extreme acidity

KW - Fluorescent probe

KW - Imaging

KW - pH

UR - http://www.scopus.com/inward/record.url?scp=84969780594&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2016.04.084

DO - 10.1016/j.snb.2016.04.084

M3 - Journal article

AN - SCOPUS:84969780594

SN - 0925-4005

VL - 234

SP - 534

EP - 540

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

ER -

A novel fluorescent probe for sensing and imaging extreme acidity

Abstract

Scopus Subject Areas

User-Defined Keywords

Access to Document

Other files and links

Fingerprint

Cite this