A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α

Lihua Lu, Modi Wang, Zhifeng Mao, Tian Shu Kang, Xiu Ping Chen, Jin Jian Lu, Chung Hang Leung, Edmond Dik Lung MA*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

A novel dinuclear Ir(III) complex 5 was discovered to be specific to G-quadruplex DNA, and was utilized in a label-free G-quadruplex-based detection platform for transcription factor activity. The principle of this assay was demonstrated by using HIF-1α as a model protein. Moreover, this HIF-1α detection assay exhibited potential use for biological sample analysis.

Original languageEnglish
Article number22458
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 2 Mar 2016

Scopus Subject Areas

  • General

Fingerprint

Dive into the research topics of 'A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α'. Together they form a unique fingerprint.

Cite this