A novel cytotoxic oxetane ent-kauranoid from Isodon japonicus

Quanbin Han; Jixia Zhang; Yang Lu; Yunshan Wu; Qitai Zheng; Handong Sun

doi:10.1055/s-2004-827165

A novel cytotoxic oxetane ent-kauranoid from Isodon japonicus

Quanbin Han
, Jixia Zhang
, Yang Lu
, Yunshan Wu
, Qitai Zheng
, Handong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

31 Citations (Scopus)

Abstract

A novel 11,20:1,20-diepoxy-ent-kaurane diterpenoid, maoyecrystal I (1), was isolated from Isodon japonicus, and its structure was elucidated by spectroscopic methods and comparison with another new ent-kauranoid, rubescensin W (2) from Isodon rubescens var. taihangensis. The structure of 2 was determined by single crystal X-ray diffraction analysis. A bioassay of their cytotoxity against K562 cells showed that the oxetane group of 1 might be a bioactive moiety.

Original language	English
Pages (from-to)	581-584
Number of pages	4
Journal	Planta Medica
Volume	70
Issue number	6
DOIs	https://doi.org/10.1055/s-2004-827165
Publication status	Published - Jun 2004

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title = "A novel cytotoxic oxetane ent-kauranoid from Isodon japonicus",

abstract = "A novel 11,20:1,20-diepoxy-ent-kaurane diterpenoid, maoyecrystal I (1), was isolated from Isodon japonicus, and its structure was elucidated by spectroscopic methods and comparison with another new ent-kauranoid, rubescensin W (2) from Isodon rubescens var. taihangensis. The structure of 2 was determined by single crystal X-ray diffraction analysis. A bioassay of their cytotoxity against K562 cells showed that the oxetane group of 1 might be a bioactive moiety.",

author = "Quanbin Han and Jixia Zhang and Yang Lu and Yunshan Wu and Qitai Zheng and Handong Sun",

year = "2004",

month = jun,

doi = "10.1055/s-2004-827165",

language = "English",

volume = "70",

pages = "581--584",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

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TY - JOUR

T1 - A novel cytotoxic oxetane ent-kauranoid from Isodon japonicus

AU - Han, Quanbin

AU - Zhang, Jixia

AU - Lu, Yang

AU - Wu, Yunshan

AU - Zheng, Qitai

AU - Sun, Handong

PY - 2004/6

Y1 - 2004/6

N2 - A novel 11,20:1,20-diepoxy-ent-kaurane diterpenoid, maoyecrystal I (1), was isolated from Isodon japonicus, and its structure was elucidated by spectroscopic methods and comparison with another new ent-kauranoid, rubescensin W (2) from Isodon rubescens var. taihangensis. The structure of 2 was determined by single crystal X-ray diffraction analysis. A bioassay of their cytotoxity against K562 cells showed that the oxetane group of 1 might be a bioactive moiety.

AB - A novel 11,20:1,20-diepoxy-ent-kaurane diterpenoid, maoyecrystal I (1), was isolated from Isodon japonicus, and its structure was elucidated by spectroscopic methods and comparison with another new ent-kauranoid, rubescensin W (2) from Isodon rubescens var. taihangensis. The structure of 2 was determined by single crystal X-ray diffraction analysis. A bioassay of their cytotoxity against K562 cells showed that the oxetane group of 1 might be a bioactive moiety.

UR - https://www.scopus.com/pages/publications/3042714344

U2 - 10.1055/s-2004-827165

DO - 10.1055/s-2004-827165

M3 - Journal article

SN - 0032-0943

VL - 70

SP - 581

EP - 584

JO - Planta Medica

JF - Planta Medica

IS - 6

ER -

A novel cytotoxic oxetane ent-kauranoid from Isodon japonicus

Abstract

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