A novel cytotoxic oxetane ent-kauranoid from Isodon japonicus

Quanbin Han, Jixia Zhang, Yang Lu, Yunshan Wu, Qitai Zheng, Handong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

27 Citations (Scopus)


A novel 11,20:1,20-diepoxy-ent-kaurane diterpenoid, maoyecrystal I (1), was isolated from Isodon japonicus, and its structure was elucidated by spectroscopic methods and comparison with another new ent-kauranoid, rubescensin W (2) from Isodon rubescens var. taihangensis. The structure of 2 was determined by single crystal X-ray diffraction analysis. A bioassay of their cytotoxity against K562 cells showed that the oxetane group of 1 might be a bioactive moiety.

Original languageEnglish
Pages (from-to)581-584
Number of pages4
JournalPlanta Medica
Issue number6
Publication statusPublished - Jun 2004

Scopus Subject Areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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