A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells

Huan He; Dong Wei Li; Li Yun Yang; Li Fu; Xunjin ZHU; Rick W K WONG; Feng Lei Jiang; Yi Liu

doi:10.1038/srep13543

A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells

Huan He, Dong Wei Li, Li Yun Yang, Li Fu, Xunjin ZHU, Rick W K WONG, Feng Lei Jiang, Yi Liu^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.

Original language	English
Article number	13543
Journal	Scientific Reports
Volume	5
DOIs	https://doi.org/10.1038/srep13543
Publication status	Published - 4 Sep 2015

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title = "A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells",

abstract = "Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.",

author = "Huan He and Li, {Dong Wei} and Yang, {Li Yun} and Li Fu and Xunjin ZHU and WONG, {Rick W K} and Jiang, {Feng Lei} and Yi Liu",

note = "Funding Information: The authors gratefully acknowledge the financial support from National Science Fund for Distinguished Young Scholars of China (21225313), National Natural Science Foundation of China (21303126, 21473125), Natural Science Foundation of Hubei Province (2014CFA003), Fundamental Research Funds for the Central Universities (2042014kf0287) and Large-scale Instrument And Equipment Sharing Foundation of Wuhan University.",

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T1 - A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells

AU - He, Huan

AU - Li, Dong Wei

AU - Yang, Li Yun

AU - Fu, Li

AU - ZHU, Xunjin

AU - WONG, Rick W K

AU - Jiang, Feng Lei

AU - Liu, Yi

N1 - Funding Information: The authors gratefully acknowledge the financial support from National Science Fund for Distinguished Young Scholars of China (21225313), National Natural Science Foundation of China (21303126, 21473125), Natural Science Foundation of Hubei Province (2014CFA003), Fundamental Research Funds for the Central Universities (2042014kf0287) and Large-scale Instrument And Equipment Sharing Foundation of Wuhan University.

PY - 2015/9/4

Y1 - 2015/9/4

N2 - Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.

AB - Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.

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A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells

Abstract

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