A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells

Huan He, Dong Wei Li, Li Yun Yang, Li Fu, Xunjin ZHU, Rick W K WONG, Feng Lei Jiang, Yi Liu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.

Original languageEnglish
Article number13543
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - 4 Sep 2015

Scopus Subject Areas

  • General

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