@article{4aeeabdd70b449239876a77b2dd02beb,
title = "A novel bifunctional mitochondria-targeted anticancer agent with high selectivity for cancer cells",
abstract = "Mitochondria have recently emerged as novel targets for cancer therapy due to its important roles in fundamental cellular function. Discovery of new chemotherapeutic agents that allow for simultaneous treatment and visualization of cancer is urgent. Herein, we demonstrate a novel bifunctional mitochondria-targeted anticancer agent (FPB), exhibiting both imaging capability and anticancer activity. It can selectively accumulate in mitochondria and induce cell apoptosis. Notably, it results in much higher toxicity toward cancer cells owing to much higher uptake by cancer cells. These features make it highly attractive in cancer imaging and treatment.",
author = "Huan He and Li, {Dong Wei} and Yang, {Li Yun} and Li Fu and Xunjin ZHU and WONG, {Rick W K} and Jiang, {Feng Lei} and Yi Liu",
note = "Funding Information: The authors gratefully acknowledge the financial support from National Science Fund for Distinguished Young Scholars of China (21225313), National Natural Science Foundation of China (21303126, 21473125), Natural Science Foundation of Hubei Province (2014CFA003), Fundamental Research Funds for the Central Universities (2042014kf0287) and Large-scale Instrument And Equipment Sharing Foundation of Wuhan University.",
year = "2015",
month = sep,
day = "4",
doi = "10.1038/srep13543",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}
