A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius

Li Mei Li; Guo You Li; Wei Lie Xiao; Yan Zhou; Sheng Hong Li; Sheng Xiong Huang; Quan Bin Han; Li Sheng Ding; Li Guang Lou; Han Dong Sun

doi:10.1016/j.tetlet.2006.05.025

A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius

Li Mei Li
, Guo You Li
, Wei Lie Xiao
, Yan Zhou
, Sheng Hong Li
, Sheng Xiong Huang
, Quan Bin Han
, Li Sheng Ding
, Li Guang Lou
, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

9 Citations (Scopus)

Abstract

Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8→11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC₅₀ value of 4.97 μM.

Original language	English
Pages (from-to)	5187-5190
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	29
DOIs	https://doi.org/10.1016/j.tetlet.2006.05.025
Publication status	Published - 17 Jul 2006

User-Defined Keywords

Cytotoxicity
Isodon parvifolius
Labiatae
NMR data
Parvifolines X and Y

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10.1016/j.tetlet.2006.05.025

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@article{f570d6aa4e6947af8f64fe13134b8cb2,

title = "A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius",

abstract = "Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8→11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC50 value of 4.97 μM.",

keywords = "Cytotoxicity, Isodon parvifolius, Labiatae, NMR data, Parvifolines X and Y",

author = "Li, \{Li Mei\} and Li, \{Guo You\} and Xiao, \{Wei Lie\} and Yan Zhou and Li, \{Sheng Hong\} and Huang, \{Sheng Xiong\} and Han, \{Quan Bin\} and Ding, \{Li Sheng\} and Lou, \{Li Guang\} and Sun, \{Han Dong\}",

note = "Funding Information: Financial support of the Natural Science Foundation of Yunnan Province (No. 2004C0008Z), and the National Natural Science Foundation of China (No. 20502026 to Q.-B. Han.) are gratefully acknowledged. ",

year = "2006",

month = jul,

day = "17",

doi = "10.1016/j.tetlet.2006.05.025",

language = "English",

volume = "47",

pages = "5187--5190",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

number = "29",

}

TY - JOUR

T1 - A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius

AU - Li, Li Mei

AU - Li, Guo You

AU - Xiao, Wei Lie

AU - Zhou, Yan

AU - Li, Sheng Hong

AU - Huang, Sheng Xiong

AU - Han, Quan Bin

AU - Ding, Li Sheng

AU - Lou, Li Guang

AU - Sun, Han Dong

N1 - Funding Information: Financial support of the Natural Science Foundation of Yunnan Province (No. 2004C0008Z), and the National Natural Science Foundation of China (No. 20502026 to Q.-B. Han.) are gratefully acknowledged.

PY - 2006/7/17

Y1 - 2006/7/17

N2 - Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8→11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC50 value of 4.97 μM.

AB - Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8→11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC50 value of 4.97 μM.

KW - Cytotoxicity

KW - Isodon parvifolius

KW - Labiatae

KW - NMR data

KW - Parvifolines X and Y

UR - https://www.scopus.com/pages/publications/33745002520

U2 - 10.1016/j.tetlet.2006.05.025

DO - 10.1016/j.tetlet.2006.05.025

M3 - Journal article

SN - 0040-4039

VL - 47

SP - 5187

EP - 5190

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 29

ER -

A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius

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