A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius

Li Mei Li; Guo You Li; Wei Lie Xiao; Yan Zhou; Sheng Hong Li; Sheng Xiong Huang; Quan Bin Han; Li Sheng Ding; Li Guang Lou; Han Dong Sun

doi:10.1016/j.tetlet.2006.05.025

A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius

Li Mei Li, Guo You Li, Wei Lie Xiao, Yan Zhou, Sheng Hong Li, Sheng Xiong Huang, Quan Bin Han, Li Sheng Ding, Li Guang Lou, Han Dong Sun^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

8 Citations (Scopus)

Abstract

Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8→11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC₅₀ value of 4.97 μM.

Original language	English
Pages (from-to)	5187-5190
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	29
DOIs	https://doi.org/10.1016/j.tetlet.2006.05.025
Publication status	Published - 17 Jul 2006

User-Defined Keywords

Cytotoxicity
Isodon parvifolius
Labiatae
NMR data
Parvifolines X and Y

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10.1016/j.tetlet.2006.05.025

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@article{f570d6aa4e6947af8f64fe13134b8cb2,

title = "A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius",

abstract = "Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8→11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC50 value of 4.97 μM.",

keywords = "Cytotoxicity, Isodon parvifolius, Labiatae, NMR data, Parvifolines X and Y",

author = "Li, {Li Mei} and Li, {Guo You} and Xiao, {Wei Lie} and Yan Zhou and Li, {Sheng Hong} and Huang, {Sheng Xiong} and Han, {Quan Bin} and Ding, {Li Sheng} and Lou, {Li Guang} and Sun, {Han Dong}",

note = "Funding Information: Financial support of the Natural Science Foundation of Yunnan Province (No. 2004C0008Z), and the National Natural Science Foundation of China (No. 20502026 to Q.-B. Han.) are gratefully acknowledged. ",

year = "2006",

month = jul,

day = "17",

doi = "10.1016/j.tetlet.2006.05.025",

language = "English",

volume = "47",

pages = "5187--5190",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

number = "29",

}

TY - JOUR

T1 - A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius

AU - Li, Li Mei

AU - Li, Guo You

AU - Xiao, Wei Lie

AU - Zhou, Yan

AU - Li, Sheng Hong

AU - Huang, Sheng Xiong

AU - Han, Quan Bin

AU - Ding, Li Sheng

AU - Lou, Li Guang

AU - Sun, Han Dong

N1 - Funding Information: Financial support of the Natural Science Foundation of Yunnan Province (No. 2004C0008Z), and the National Natural Science Foundation of China (No. 20502026 to Q.-B. Han.) are gratefully acknowledged.

PY - 2006/7/17

Y1 - 2006/7/17

N2 - Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8→11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC50 value of 4.97 μM.

AB - Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8→11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC50 value of 4.97 μM.

KW - Cytotoxicity

KW - Isodon parvifolius

KW - Labiatae

KW - NMR data

KW - Parvifolines X and Y

UR - http://www.scopus.com/inward/record.url?scp=33745002520&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2006.05.025

DO - 10.1016/j.tetlet.2006.05.025

M3 - Journal article

SN - 0040-4039

VL - 47

SP - 5187

EP - 5190

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 29

ER -

A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius

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