A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius

Li Mei Li, Guo You Li, Wei Lie Xiao, Yan Zhou, Sheng Hong Li, Sheng Xiong Huang, Quan Bin Han, Li Sheng Ding, Li Guang Lou, Han Dong Sun*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

8 Citations (Scopus)


Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8→11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC50 value of 4.97 μM.

Original languageEnglish
Pages (from-to)5187-5190
Number of pages4
JournalTetrahedron Letters
Issue number29
Publication statusPublished - 17 Jul 2006

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Cytotoxicity
  • Isodon parvifolius
  • Labiatae
  • NMR data
  • Parvifolines X and Y


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