A new peptide-based chemosensor for selective imaging of copper ion and hydrogen sulfide in living cells

Chaowei Hao, Yongxin Li, Baomin Fan, Guangzhi Zeng, Danni Zhang, Zhaoxiang BIAN*, Jiang Wu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Hydrogen sulfide (H2S), like CO and NO, is an endogenous gas signal molecule that can play a vital role in many physiological processes. Therefore, it's of great significance to study the efficient and sensitive imaging technology of H2S in vivo. Copper is an essential trace element in the human body that is very important for many cellular functions and related metabolic processes. In this study we report the design of a peptide L (FITC-Ahx-His-Glu-Phe-His-NH2) that can act as an “On-Off-On” fluorescent chemical sensor to detect Cu2+ and S2−, and cysteine (Cys) and glutathione (GSH) can also replace Cu2+ from L-Cu system. The capability of this peptide fluorescent probe to detect H2S in HeLa cells is also evaluated.

Original languageEnglish
Article number104658
JournalMicrochemical Journal
Volume154
DOIs
Publication statusPublished - May 2020

Scopus Subject Areas

  • Analytical Chemistry
  • Spectroscopy

User-Defined Keywords

  • Cells imaging
  • Copper ion detection
  • Hydrogen sulfide detection
  • Peptide-based

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