@article{65034dde32984b0b8a73ec9b62eac8bc,
title = "A new peptide-based chemosensor for selective imaging of copper ion and hydrogen sulfide in living cells",
abstract = "Hydrogen sulfide (H2S), like CO and NO, is an endogenous gas signal molecule that can play a vital role in many physiological processes. Therefore, it's of great significance to study the efficient and sensitive imaging technology of H2S in vivo. Copper is an essential trace element in the human body that is very important for many cellular functions and related metabolic processes. In this study we report the design of a peptide L (FITC-Ahx-His-Glu-Phe-His-NH2) that can act as an “On-Off-On” fluorescent chemical sensor to detect Cu2+ and S2−, and cysteine (Cys) and glutathione (GSH) can also replace Cu2+ from L-Cu system. The capability of this peptide fluorescent probe to detect H2S in HeLa cells is also evaluated.",
keywords = "Cells imaging, Copper ion detection, Hydrogen sulfide detection, Peptide-based",
author = "Chaowei Hao and Yongxin Li and Baomin Fan and Guangzhi Zeng and Danni Zhang and Zhaoxiang Bian and Jiang Wu",
note = "Funding Information: We are grateful to the National Natural Science Foundation of China ( 21572198 ) and the Applied Basic Research Project of Yunnan Province ( 2017FA004 ) and Yunnan Provincial Key Laboratory Construction Plan Funding and Yunnan Provincial Engineering Research Center Construction Plan Funding of Universities for their financial support. Funding Information: We are grateful to the National Natural Science Foundation of China (21572198) and the Applied Basic Research Project of Yunnan Province (2017FA004) and Yunnan Provincial Key LaboratoryConstruction Plan Funding and Yunnan Provincial Engineering Research Center Construction Plan Funding of Universities for their financial support.",
year = "2020",
month = may,
doi = "10.1016/j.microc.2020.104658",
language = "English",
volume = "154",
journal = "Microchemical Journal",
issn = "0026-265X",
publisher = "Elsevier Inc.",
}