A New Index Based on Serum Creatinine and Cystatin C Can Predict the Risks of Sarcopenia, Falls and Fractures in Old Patients with Low Bone Mineral Density

Jiaying Ge, Jiangping Zeng, Huihui Ma, Siqi Sun, Zheng Zhao, Yujie Jing, Chunhua Qian, Zhaoliang Fei, Ran Cui, Shen Qu, Ge Zhang*, Hui Sheng*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

2 Citations (Scopus)

Abstract

As new screening tools for sarcopenia, the serum sarcopenia index (SI) and creatinine/cystatin C ratio (CCR) had not been confirmd in a population with a high fragility fracture risk. This study aimed to evaluate whether SI and CCR indicators are useful for diagnosing sarcopenia and to determine their prediction values for future falls and fractures. A total of 404 hospitalized older adults were enrolled in this longitudinal follow-up study (mean age = 66.43 ± 6.80 years). The receiver operating curve (ROC) was used to assess the diagnostic accuracy of SI and CCR. Backward-selection binary logistic regression was applied to develop the optimal models for the diagnosis of new falls and fractures. SI had a significantly higher area under the curve (AUC) than CCR for predicting sarcopenia. The optimal models had acceptable discriminative powers for predicting new falls and fractures. Lower SI and CCR are the independent risks for sarcopenia, new falls, and fractures in the low-BMD population. SI and CCR, as easily accessible biochemical markers, may be useful in the detection of sarcopenia and in predicting the occurrence of new falls and fractures in patients with low BMD who have not previously experienced falls or fractures. However, further external validations are required.

Original languageEnglish
Article number5020
Number of pages12
JournalNutrients
Volume14
Issue number23
Early online date25 Nov 2022
DOIs
Publication statusPublished - Dec 2022

Scopus Subject Areas

  • Food Science
  • Nutrition and Dietetics

User-Defined Keywords

  • low bone mineral density
  • sarcopenia
  • creatinine
  • cystatin C
  • fall
  • fracture

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