A new fungicide produced by a Streptomyces sp. GAAS7310

Guangying Chen; Birun Lin; Yongcheng Lin; Fengchun Xie; Wen Lu; David W F FONG

doi:10.1038/ja.2005.70

A new fungicide produced by a Streptomyces sp. GAAS7310

Guangying Chen, Birun Lin, Yongcheng Lin^*, Fengchun Xie, Wen Lu, David W F FONG

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Journal article › peer-review

36 Citations (Scopus)

Abstract

Directed bioassay guided fraction led to a new macrodiolide antimycin A₁₇ (1), isolated from a Streptomyces sp. GAAS7310, which showed significant antimicrobial activity against eleven fungal species, including Curvularia lunata (Wakker) Boed, Rhizopus nigrtcans Ehrb and Colletotrichum nigrum EL. et Halst. The structure was unambiguously established by interpretation of 1D and 2D NMR data and comparison with the known antimycin A_1a.

Original language	English
Pages (from-to)	519-522
Number of pages	4
Journal	Journal of Antibiotics
Volume	58
Issue number	8
DOIs	https://doi.org/10.1038/ja.2005.70
Publication status	Published - Aug 2005

Scopus Subject Areas

Pharmacology
Drug Discovery

User-Defined Keywords

Actinomycete
Antimicrobial activity
Antimycin
Fungicide
Macrodiolide
Streptomyces sp.

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10.1038/ja.2005.70

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title = "A new fungicide produced by a Streptomyces sp. GAAS7310",

abstract = "Directed bioassay guided fraction led to a new macrodiolide antimycin A17 (1), isolated from a Streptomyces sp. GAAS7310, which showed significant antimicrobial activity against eleven fungal species, including Curvularia lunata (Wakker) Boed, Rhizopus nigrtcans Ehrb and Colletotrichum nigrum EL. et Halst. The structure was unambiguously established by interpretation of 1D and 2D NMR data and comparison with the known antimycin A1a.",

keywords = "Actinomycete, Antimicrobial activity, Antimycin, Fungicide, Macrodiolide, Streptomyces sp.",

author = "Guangying Chen and Birun Lin and Yongcheng Lin and Fengchun Xie and Wen Lu and FONG, {David W F}",

note = "Funding Information: Acknowledgments This work was supported by the National Natural Science Foundation of China (20072058), the 863 Foundation of China (2003AA624010), the Natural Science Foundation of Guangdong Province, China (980317).",

year = "2005",

month = aug,

doi = "10.1038/ja.2005.70",

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volume = "58",

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journal = "Journal of Antibiotics",

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T1 - A new fungicide produced by a Streptomyces sp. GAAS7310

AU - Chen, Guangying

AU - Lin, Birun

AU - Lin, Yongcheng

AU - Xie, Fengchun

AU - Lu, Wen

AU - FONG, David W F

N1 - Funding Information: Acknowledgments This work was supported by the National Natural Science Foundation of China (20072058), the 863 Foundation of China (2003AA624010), the Natural Science Foundation of Guangdong Province, China (980317).

PY - 2005/8

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N2 - Directed bioassay guided fraction led to a new macrodiolide antimycin A17 (1), isolated from a Streptomyces sp. GAAS7310, which showed significant antimicrobial activity against eleven fungal species, including Curvularia lunata (Wakker) Boed, Rhizopus nigrtcans Ehrb and Colletotrichum nigrum EL. et Halst. The structure was unambiguously established by interpretation of 1D and 2D NMR data and comparison with the known antimycin A1a.

AB - Directed bioassay guided fraction led to a new macrodiolide antimycin A17 (1), isolated from a Streptomyces sp. GAAS7310, which showed significant antimicrobial activity against eleven fungal species, including Curvularia lunata (Wakker) Boed, Rhizopus nigrtcans Ehrb and Colletotrichum nigrum EL. et Halst. The structure was unambiguously established by interpretation of 1D and 2D NMR data and comparison with the known antimycin A1a.

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KW - Antimicrobial activity

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KW - Fungicide

KW - Macrodiolide

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JO - Journal of Antibiotics

JF - Journal of Antibiotics

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A new fungicide produced by a Streptomyces sp. GAAS7310

Abstract

Scopus Subject Areas

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