Directed bioassay guided fraction led to a new macrodiolide antimycin A17 (1), isolated from a Streptomyces sp. GAAS7310, which showed significant antimicrobial activity against eleven fungal species, including Curvularia lunata (Wakker) Boed, Rhizopus nigrtcans Ehrb and Colletotrichum nigrum EL. et Halst. The structure was unambiguously established by interpretation of 1D and 2D NMR data and comparison with the known antimycin A1a.
|Number of pages||4|
|Journal||Journal of Antibiotics|
|Publication status||Published - Aug 2005|
Scopus Subject Areas
- Drug Discovery
- Antimicrobial activity
- Streptomyces sp.