TY - JOUR
T1 - A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae
AU - Hong, Ming
AU - Zhang, Yongsheng
AU - Li, Sha
AU - Tan, Hor Yue
AU - Wang, Ning
AU - Mu, Shuzhen
AU - Hao, Xiaojiang
AU - Feng, Yibin
N1 - Funding Information:
This work was financially supported by the University of Hong Kong (project codes: 104002889 and 104003422), Wong’s donation (project code: 200006276), the donation of Gaia Family Trust, New Zealand (project code: 200007008), and the Zhejiang Provincial Nature Science Foundation (Y2100684), the Foundation of Zhejiang Provincial Science and Technology Program (2012R10044-03), the National Science Foundation of China, NSFC (No.81573700), and the Zhejiang Provincial Natural Science Foundation, ZJNSFC (No. LY16H280004).
Publisher Copyright:
© 2017 by the authors.
PY - 2017/10
Y1 - 2017/10
N2 - Fructus schisandrae (Wuweizi in Chinese), a common traditional Chinese herbal medicine, has been used for centuries to treat chronic liver disease. The therapeutic efficacy of Wuweizi has also been validated in clinical practice. In this study, molecular docking and network analysis were carried out to explore the hepatoprotective mechanism of Wuweizi as an effective therapeutic approach to treat liver disease. Multiple active compounds of Wuweizi were docked with 44 protein targets related with viral hepatitis, fatty liver, liver fibrosis, cirrhosis, and liver cancer. A compound–target network was constructed through network pharmacology analysis, predicting the relationships of active ingredients to the targets. Our results demonstrated that schisantherin, schisandrin B, schisandrol B, kadsurin, Wuweizisu C, Gomisin A, Gomisin G, and angeloylgomisin may target with 21 intracellular proteins associated with liver diseases, especially with fatty liver disease. The CYP2E1, PPARα, and AMPK genes and their related pathway may play a pivotal role in the hepatoprotective effects of Wuweizi. The network pharmacology strategy used provides a forceful tool for searching the action mechanism of traditional herbal medicines and novel bioactive ingredients.
AB - Fructus schisandrae (Wuweizi in Chinese), a common traditional Chinese herbal medicine, has been used for centuries to treat chronic liver disease. The therapeutic efficacy of Wuweizi has also been validated in clinical practice. In this study, molecular docking and network analysis were carried out to explore the hepatoprotective mechanism of Wuweizi as an effective therapeutic approach to treat liver disease. Multiple active compounds of Wuweizi were docked with 44 protein targets related with viral hepatitis, fatty liver, liver fibrosis, cirrhosis, and liver cancer. A compound–target network was constructed through network pharmacology analysis, predicting the relationships of active ingredients to the targets. Our results demonstrated that schisantherin, schisandrin B, schisandrol B, kadsurin, Wuweizisu C, Gomisin A, Gomisin G, and angeloylgomisin may target with 21 intracellular proteins associated with liver diseases, especially with fatty liver disease. The CYP2E1, PPARα, and AMPK genes and their related pathway may play a pivotal role in the hepatoprotective effects of Wuweizi. The network pharmacology strategy used provides a forceful tool for searching the action mechanism of traditional herbal medicines and novel bioactive ingredients.
KW - Hepatoprotective effect
KW - Network pharmacology
KW - Wuweizi
UR - http://www.scopus.com/inward/record.url?scp=85030768515&partnerID=8YFLogxK
U2 - 10.3390/molecules22101617
DO - 10.3390/molecules22101617
M3 - Journal article
C2 - 28956809
AN - SCOPUS:85030768515
SN - 1420-3049
VL - 22
JO - Molecules
JF - Molecules
IS - 10
M1 - 1617
ER -
