A natural product-like inhibitor of NEDD8-activating enzyme

Chung Hang Leung*, Daniel Shiu Hin Chan, Hui Yang, Ruben Abagyan, Simon Ming Yuen Lee, Guo Yuan Zhu, David W F FONG, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)

Abstract

The natural product-like 6,6′-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.

Original languageEnglish
Pages (from-to)2511-2513
Number of pages3
JournalChemical Communications
Volume47
Issue number9
DOIs
Publication statusPublished - 14 Feb 2011

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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