A natural product-like inhibitor of NEDD8-activating enzyme

Chung Hang Leung; Daniel Shiu Hin Chan; Hui Yang; Ruben Abagyan; Simon Ming Yuen Lee; Guo Yuan Zhu; David W F FONG; Edmond Dik Lung MA

doi:10.1039/c0cc04927a

A natural product-like inhibitor of NEDD8-activating enzyme

Chung Hang Leung^*, Daniel Shiu Hin Chan, Hui Yang, Ruben Abagyan, Simon Ming Yuen Lee, Guo Yuan Zhu, David W F FONG, Edmond Dik Lung MA

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

85 Citations (Scopus)

Abstract

The natural product-like 6,6′-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.

Original language	English
Pages (from-to)	2511-2513
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	9
DOIs	https://doi.org/10.1039/c0cc04927a
Publication status	Published - 14 Feb 2011

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c0cc04927a

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title = "A natural product-like inhibitor of NEDD8-activating enzyme",

abstract = "The natural product-like 6,6′-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.",

author = "Leung, {Chung Hang} and Chan, {Daniel Shiu Hin} and Hui Yang and Ruben Abagyan and Lee, {Simon Ming Yuen} and Zhu, {Guo Yuan} and FONG, {David W F} and MA, {Edmond Dik Lung}",

year = "2011",

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doi = "10.1039/c0cc04927a",

language = "English",

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journal = "Chemical Communications",

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T1 - A natural product-like inhibitor of NEDD8-activating enzyme

AU - Leung, Chung Hang

AU - Chan, Daniel Shiu Hin

AU - Yang, Hui

AU - Abagyan, Ruben

AU - Lee, Simon Ming Yuen

AU - Zhu, Guo Yuan

AU - FONG, David W F

AU - MA, Edmond Dik Lung

PY - 2011/2/14

Y1 - 2011/2/14

N2 - The natural product-like 6,6′-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.

AB - The natural product-like 6,6′-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.

UR - http://www.scopus.com/inward/record.url?scp=79952261355&partnerID=8YFLogxK

U2 - 10.1039/c0cc04927a

DO - 10.1039/c0cc04927a

M3 - Journal article

C2 - 21240405

AN - SCOPUS:79952261355

SN - 1359-7345

VL - 47

SP - 2511

EP - 2513

JO - Chemical Communications

JF - Chemical Communications

IS - 9

ER -

A natural product-like inhibitor of NEDD8-activating enzyme

Abstract

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