A nanoencapsulation suspension biomimetic of milk structure for enhanced maternal and fetal absorptions of DHA to improve early brain development

Jie Zeng; Wenxuan Yu; Xiaoli Dong; Shanting Zhao; Zhe Wang; Yajie Liu; Man Sau Wong; Yi Wang

doi:10.1016/j.nano.2018.09.006

A nanoencapsulation suspension biomimetic of milk structure for enhanced maternal and fetal absorptions of DHA to improve early brain development

Jie Zeng, Wenxuan Yu, Xiaoli Dong, Shanting Zhao, Zhe Wang, Yajie Liu, Man Sau Wong^*, Yi Wang^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

16 Citations (Scopus)

Abstract

Docosahexaenoic acid (DHA) is one ω-3 fatty acid that is essential for the development and function of the brain. However, a large number of clinical trials found that the DHA supplementation showed no advantage on mental and motor skill development in term infants. A strategy based on DHA nanoencapsulation (nano FO) using an edible plant protein, zein, mimicking the milk structure is applied for enhanced maternal and fetal absorptions of DHA to improve early brain development. The nano FO achieved increased absorption in GI tract, enhanced delivery to the maternal, fetal, and offspring brains, and reduced fatty acid accumulation in the fetal liver. In the behavior assessments, the nano FO diet showed enhanced learning and memory improvement compared to the normal FO diet. It indicated that zein nanoencapsulation is with high potential for drug and nutrient deliveries to brain and through placenta to fetus with no toxicity concern.

Original language	English
Pages (from-to)	119-128
Number of pages	10
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	15
Issue number	1
DOIs	https://doi.org/10.1016/j.nano.2018.09.006
Publication status	Published - Jan 2019

Scopus Subject Areas

Bioengineering
Medicine (miscellaneous)
Molecular Medicine
Biomedical Engineering
General Materials Science
Pharmaceutical Science

User-Defined Keywords

Absorption
Brain
DHA
Encapsulation
Fetus

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10.1016/j.nano.2018.09.006

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title = "A nanoencapsulation suspension biomimetic of milk structure for enhanced maternal and fetal absorptions of DHA to improve early brain development",

abstract = "Docosahexaenoic acid (DHA) is one ω-3 fatty acid that is essential for the development and function of the brain. However, a large number of clinical trials found that the DHA supplementation showed no advantage on mental and motor skill development in term infants. A strategy based on DHA nanoencapsulation (nano FO) using an edible plant protein, zein, mimicking the milk structure is applied for enhanced maternal and fetal absorptions of DHA to improve early brain development. The nano FO achieved increased absorption in GI tract, enhanced delivery to the maternal, fetal, and offspring brains, and reduced fatty acid accumulation in the fetal liver. In the behavior assessments, the nano FO diet showed enhanced learning and memory improvement compared to the normal FO diet. It indicated that zein nanoencapsulation is with high potential for drug and nutrient deliveries to brain and through placenta to fetus with no toxicity concern.",

keywords = "Absorption, Brain, DHA, Encapsulation, Fetus",

author = "Jie Zeng and Wenxuan Yu and Xiaoli Dong and Shanting Zhao and Zhe Wang and Yajie Liu and Wong, {Man Sau} and Yi Wang",

note = "Funding Information: This work is financially supported by the Shenzhen Basic Research (Layout of Disciplines) Project Fund ( JCYJ20170413154810633 ), the General Research Fund (GRF) of Hong Kong ( PolyU 153343/16P ), the Health and Medical Research Fund (HMRF) of the Food and Health Bureau of Hong Kong ( 03144126 , 05161016 ), and Central Research Fund of the Hong Kong Polytechnic University ( 4-BCA8 , G-UA4C , G-YBJ7 , and G-YBU1 ). Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

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AU - Zhao, Shanting

AU - Wang, Zhe

AU - Liu, Yajie

AU - Wong, Man Sau

AU - Wang, Yi

N1 - Funding Information: This work is financially supported by the Shenzhen Basic Research (Layout of Disciplines) Project Fund ( JCYJ20170413154810633 ), the General Research Fund (GRF) of Hong Kong ( PolyU 153343/16P ), the Health and Medical Research Fund (HMRF) of the Food and Health Bureau of Hong Kong ( 03144126 , 05161016 ), and Central Research Fund of the Hong Kong Polytechnic University ( 4-BCA8 , G-UA4C , G-YBJ7 , and G-YBU1 ). Publisher Copyright: © 2018 Elsevier Inc.

PY - 2019/1

Y1 - 2019/1

N2 - Docosahexaenoic acid (DHA) is one ω-3 fatty acid that is essential for the development and function of the brain. However, a large number of clinical trials found that the DHA supplementation showed no advantage on mental and motor skill development in term infants. A strategy based on DHA nanoencapsulation (nano FO) using an edible plant protein, zein, mimicking the milk structure is applied for enhanced maternal and fetal absorptions of DHA to improve early brain development. The nano FO achieved increased absorption in GI tract, enhanced delivery to the maternal, fetal, and offspring brains, and reduced fatty acid accumulation in the fetal liver. In the behavior assessments, the nano FO diet showed enhanced learning and memory improvement compared to the normal FO diet. It indicated that zein nanoencapsulation is with high potential for drug and nutrient deliveries to brain and through placenta to fetus with no toxicity concern.

AB - Docosahexaenoic acid (DHA) is one ω-3 fatty acid that is essential for the development and function of the brain. However, a large number of clinical trials found that the DHA supplementation showed no advantage on mental and motor skill development in term infants. A strategy based on DHA nanoencapsulation (nano FO) using an edible plant protein, zein, mimicking the milk structure is applied for enhanced maternal and fetal absorptions of DHA to improve early brain development. The nano FO achieved increased absorption in GI tract, enhanced delivery to the maternal, fetal, and offspring brains, and reduced fatty acid accumulation in the fetal liver. In the behavior assessments, the nano FO diet showed enhanced learning and memory improvement compared to the normal FO diet. It indicated that zein nanoencapsulation is with high potential for drug and nutrient deliveries to brain and through placenta to fetus with no toxicity concern.

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A nanoencapsulation suspension biomimetic of milk structure for enhanced maternal and fetal absorptions of DHA to improve early brain development

Abstract

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