A naïve hypergraph model of brain networks

This paper extended the concept of motif by maximum cliques defined as "hyperedges" in brain networks, as novel and flexible characteristic network building blocks. Based on the definition of hyperedge, a naïve brain hypergraph model was constructed from a graph model of large-scale brain functional networks during rest. Nine intrinsic hub hyperedges of functional connectivity were identified, which could be considered as the most important intrinsic information processing blocks (or units), and they also covered many components of the core brain intrinsic networks. Furthermore, these overlapped hub hyperedges were assembled into a compound structure as a core subsystem of the intrinsic brain organization.