TY - JOUR
T1 - A Multifunctional Nanoplatform Based on Graphene Quantum Dots-Cobalt Ferrite for Monitoring of Drug Delivery and Fluorescence/Magnetic Resonance Bimodal Cellular Imaging
AU - Teng, Yun
AU - Yuan, Shuai
AU - Shi, Jue
AU - Pong, Philip W.T.
N1 - This research was partially supported by the Seed Funding Program for Basic Research, Seed Funding Program for Applied Research and Small Project Funding Program from the University of Hong Kong, ITF Tier 3 funding (ITS‐104/13, ITS‐214/14), University Grants Committee of Hong Kong (AoE/P‐04/08), and the startup fund of the New Jersey Institute of Technology. J.S. was supported by the Hong Kong Research Grant Council (#C2006‐17E) and partly by the Laboratory for Synthetic Chemistry and Chemical Biology under the Health@InnoHK Program by the Innovation and Technology Commission of Hong Kong.
Publisher Copyright:
© 2022 The Authors. Advanced NanoBiomed Research published by Wiley-VCH GmbH.
PY - 2022/10
Y1 - 2022/10
N2 - A novel multifunctional nanoplatform based on graphene quantum dots (GQDs)-cobalt ferrite (CoFe2O4) is demonstrated for monitoring of the drug delivery and fluorescence/magnetic resonance imaging (MRI) bimodal cellular imaging. The nanoplatform is fabricated by assembling the GQDs onto the surface of magnetic CoFe2O4@SiO2 (CFO@SiO2) via covalent binding, subsequently conjugated with folic acid (FA). Then anticancer drug doxorubicin (DOX) is loaded on the GQD-CFO/SiO2/FA with a capacity of 65.4 wt%. The DOX/GQD-CFO@SiO2/FA can be used for monitoring of drug release by detecting the Förster resonant energy transfer (FRET) signals, with the GQDs serve as the drug carrier and the donor in FRET model. Herein, the monitoring of drug delivery is explored via the corresponding changes in FRET. The reduced brightness of T2-weighted MRI images indicates the potential of GQD-CFO@SiO2/FA to be applied as the negative contrast agent. The fluorescence/MRI bimodal cellular imaging can facilitate the transportation of drug delivery. Furthermore, the cytotoxicity assay confirms the desirable biocompatibility of GQD-CFO@SiO2/FA nanoplatform, and DOX/GQD-CFO@SiO2/FA exhibits notable cytotoxicity to HeLa cells. These results demonstrate the significantly increased therapeutic efficiency of this nanoplatform. Thus, the novel GQD-CFO@SiO2/FA can be a promising multifunctional nanoplatform with monitoring of drug delivery and fluorescence/MRI bimodal cellular imaging.
AB - A novel multifunctional nanoplatform based on graphene quantum dots (GQDs)-cobalt ferrite (CoFe2O4) is demonstrated for monitoring of the drug delivery and fluorescence/magnetic resonance imaging (MRI) bimodal cellular imaging. The nanoplatform is fabricated by assembling the GQDs onto the surface of magnetic CoFe2O4@SiO2 (CFO@SiO2) via covalent binding, subsequently conjugated with folic acid (FA). Then anticancer drug doxorubicin (DOX) is loaded on the GQD-CFO/SiO2/FA with a capacity of 65.4 wt%. The DOX/GQD-CFO@SiO2/FA can be used for monitoring of drug release by detecting the Förster resonant energy transfer (FRET) signals, with the GQDs serve as the drug carrier and the donor in FRET model. Herein, the monitoring of drug delivery is explored via the corresponding changes in FRET. The reduced brightness of T2-weighted MRI images indicates the potential of GQD-CFO@SiO2/FA to be applied as the negative contrast agent. The fluorescence/MRI bimodal cellular imaging can facilitate the transportation of drug delivery. Furthermore, the cytotoxicity assay confirms the desirable biocompatibility of GQD-CFO@SiO2/FA nanoplatform, and DOX/GQD-CFO@SiO2/FA exhibits notable cytotoxicity to HeLa cells. These results demonstrate the significantly increased therapeutic efficiency of this nanoplatform. Thus, the novel GQD-CFO@SiO2/FA can be a promising multifunctional nanoplatform with monitoring of drug delivery and fluorescence/MRI bimodal cellular imaging.
KW - bimodal cellular imaging
KW - cobalt ferrite (CoFeO)
KW - controlled drug delivery
KW - Förster resonant energy transfer (FRET)
KW - graphene quantum dots (GQDs)
KW - magnetic resonance imaging (MRI)
UR - http://www.scopus.com/inward/record.url?scp=85159358245&partnerID=8YFLogxK
U2 - 10.1002/anbr.202200044
DO - 10.1002/anbr.202200044
M3 - Journal article
AN - SCOPUS:85159358245
SN - 2699-9307
VL - 2
JO - Advanced NanoBiomed Research
JF - Advanced NanoBiomed Research
IS - 10
M1 - 2200044
ER -
