A MnO2 nanosheet-assisted GSH detection platform using an iridium(III) complex as a switch-on luminescent probe

Zhen Zhen Dong, Lihua Lu, Chung Nga Ko, Chao Yang, Shengnan Li, Ming Yuen Lee, Chung Hang Leung*, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

A rapid and sensitive detection platform for GSH has been constructed by combining a MnO2 nanosheet with a luminescent iridium(iii) complex [Ir(Cl-phq)2(Cl-phen)]+. The MnO2 nanosheet was prepared by using a facile one-step approach and was characterized by TEM. The luminescence intensity of the detection platform responded linearly with the GSH concentration from 1 to 200 μM (R2 = 0.9951), and the detection limit for GSH was 0.13 μM. More importantly, practical application of the detection platform for visualizing the intracellular GSH distribution in living zebrafish has also been demonstrated.

Original languageEnglish
Pages (from-to)4677-4682
Number of pages6
JournalNanoscale
Volume9
Issue number14
DOIs
Publication statusPublished - 14 Apr 2017

Scopus Subject Areas

  • Materials Science(all)

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