A MnO2 nanosheet-assisted GSH detection platform using an iridium(III) complex as a switch-on luminescent probe

Zhen Zhen Dong; Lihua Lu; Chung Nga Ko; Chao Yang; Shengnan Li; Ming Yuen Lee; Chung Hang Leung; Edmond Dik Lung MA

doi:10.1039/c6nr08357a

A MnO₂ nanosheet-assisted GSH detection platform using an iridium(III) complex as a switch-on luminescent probe

Zhen Zhen Dong, Lihua Lu, Chung Nga Ko, Chao Yang, Shengnan Li, Ming Yuen Lee, Chung Hang Leung^*, Edmond Dik Lung MA

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

97 Citations (Scopus)

Abstract

A rapid and sensitive detection platform for GSH has been constructed by combining a MnO₂ nanosheet with a luminescent iridium(iii) complex [Ir(Cl-phq)₂(Cl-phen)]⁺. The MnO₂ nanosheet was prepared by using a facile one-step approach and was characterized by TEM. The luminescence intensity of the detection platform responded linearly with the GSH concentration from 1 to 200 μM (R² = 0.9951), and the detection limit for GSH was 0.13 μM. More importantly, practical application of the detection platform for visualizing the intracellular GSH distribution in living zebrafish has also been demonstrated.

Original language	English
Pages (from-to)	4677-4682
Number of pages	6
Journal	Nanoscale
Volume	9
Issue number	14
DOIs	https://doi.org/10.1039/c6nr08357a
Publication status	Published - 14 Apr 2017

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Materials Science(all)

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title = "A MnO2 nanosheet-assisted GSH detection platform using an iridium(III) complex as a switch-on luminescent probe",

abstract = "A rapid and sensitive detection platform for GSH has been constructed by combining a MnO2 nanosheet with a luminescent iridium(iii) complex [Ir(Cl-phq)2(Cl-phen)]+. The MnO2 nanosheet was prepared by using a facile one-step approach and was characterized by TEM. The luminescence intensity of the detection platform responded linearly with the GSH concentration from 1 to 200 μM (R2 = 0.9951), and the detection limit for GSH was 0.13 μM. More importantly, practical application of the detection platform for visualizing the intracellular GSH distribution in living zebrafish has also been demonstrated.",

author = "Dong, {Zhen Zhen} and Lihua Lu and Ko, {Chung Nga} and Chao Yang and Shengnan Li and Lee, {Ming Yuen} and Leung, {Chung Hang} and MA, {Edmond Dik Lung}",

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T1 - A MnO2 nanosheet-assisted GSH detection platform using an iridium(III) complex as a switch-on luminescent probe

AU - Dong, Zhen Zhen

AU - Lu, Lihua

AU - Ko, Chung Nga

AU - Yang, Chao

AU - Li, Shengnan

AU - Lee, Ming Yuen

AU - Leung, Chung Hang

AU - MA, Edmond Dik Lung

PY - 2017/4/14

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N2 - A rapid and sensitive detection platform for GSH has been constructed by combining a MnO2 nanosheet with a luminescent iridium(iii) complex [Ir(Cl-phq)2(Cl-phen)]+. The MnO2 nanosheet was prepared by using a facile one-step approach and was characterized by TEM. The luminescence intensity of the detection platform responded linearly with the GSH concentration from 1 to 200 μM (R2 = 0.9951), and the detection limit for GSH was 0.13 μM. More importantly, practical application of the detection platform for visualizing the intracellular GSH distribution in living zebrafish has also been demonstrated.

AB - A rapid and sensitive detection platform for GSH has been constructed by combining a MnO2 nanosheet with a luminescent iridium(iii) complex [Ir(Cl-phq)2(Cl-phen)]+. The MnO2 nanosheet was prepared by using a facile one-step approach and was characterized by TEM. The luminescence intensity of the detection platform responded linearly with the GSH concentration from 1 to 200 μM (R2 = 0.9951), and the detection limit for GSH was 0.13 μM. More importantly, practical application of the detection platform for visualizing the intracellular GSH distribution in living zebrafish has also been demonstrated.

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A MnO₂ nanosheet-assisted GSH detection platform using an iridium(III) complex as a switch-on luminescent probe

Abstract

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