A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

Chung Hang Leung; Li Juan Liu; Lihua Lu; Bingyong He; Daniel W.J. Kwong; Chun Yuen Wong; Dik Lung Ma

doi:10.1039/c4cc09251a

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

Chung Hang Leung^*
, Li Juan Liu
, Lihua Lu
, Bingyong He
, Daniel W.J. Kwong
, Chun Yuen Wong
, Dik Lung Ma

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

26 Citations (Scopus)

Abstract

We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.

Original language	English
Pages (from-to)	3973-3976
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	19
DOIs	https://doi.org/10.1039/c4cc09251a
Publication status	Published - 7 Mar 2015

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title = "A metal-based tumour necrosis factor-alpha converting enzyme inhibitor",

abstract = "We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.",

author = "Leung, \{Chung Hang\} and Liu, \{Li Juan\} and Lihua Lu and Bingyong He and Kwong, \{Daniel W.J.\} and Wong, \{Chun Yuen\} and Ma, \{Dik Lung\}",

note = "This work is supported by Hong Kong Baptist University (FRG2/13-14/008), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/13121482), the Research Grants Council (HKBU/201811, HKBU/204612, and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), the Science and Technology Development Fund, Macao SAR (103/2012/A3) and the University of Macau (MYRG091(Y3-L2)-ICMS12-LCH, MYRG121(Y3-L2)-ICMS12-LCH and MRG023/LCH/2013/ICMS).",

year = "2015",

month = mar,

day = "7",

doi = "10.1039/c4cc09251a",

language = "English",

volume = "51",

pages = "3973--3976",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "19",

}

TY - JOUR

T1 - A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

AU - Leung, Chung Hang

AU - Liu, Li Juan

AU - Lu, Lihua

AU - He, Bingyong

AU - Kwong, Daniel W.J.

AU - Wong, Chun Yuen

AU - Ma, Dik Lung

N1 - This work is supported by Hong Kong Baptist University (FRG2/13-14/008), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/13121482), the Research Grants Council (HKBU/201811, HKBU/204612, and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), the Science and Technology Development Fund, Macao SAR (103/2012/A3) and the University of Macau (MYRG091(Y3-L2)-ICMS12-LCH, MYRG121(Y3-L2)-ICMS12-LCH and MRG023/LCH/2013/ICMS).

PY - 2015/3/7

Y1 - 2015/3/7

N2 - We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.

AB - We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.

UR - https://www.scopus.com/pages/publications/84923323824

U2 - 10.1039/c4cc09251a

DO - 10.1039/c4cc09251a

M3 - Journal article

C2 - 25610924

AN - SCOPUS:84923323824

SN - 1359-7345

VL - 51

SP - 3973

EP - 3976

JO - Chemical Communications

JF - Chemical Communications

IS - 19

ER -

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

Abstract

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