A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

Chung Hang Leung; Li Juan Liu; Lihua Lu; Bingyong He; Daniel W J KWONG; Chun Yuen Wong; Edmond Dik Lung MA

doi:10.1039/c4cc09251a

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

Chung Hang Leung^*, Li Juan Liu, Lihua Lu, Bingyong He, Daniel W J KWONG, Chun Yuen Wong, Edmond Dik Lung MA

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. This journal is

Original language	English
Pages (from-to)	3973-3976
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	19
DOIs	https://doi.org/10.1039/c4cc09251a
Publication status	Published - 7 Mar 2015

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "A metal-based tumour necrosis factor-alpha converting enzyme inhibitor",

abstract = "We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. This journal is",

author = "Leung, {Chung Hang} and Liu, {Li Juan} and Lihua Lu and Bingyong He and KWONG, {Daniel W J} and Wong, {Chun Yuen} and MA, {Edmond Dik Lung}",

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T1 - A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

AU - Leung, Chung Hang

AU - Liu, Li Juan

AU - Lu, Lihua

AU - He, Bingyong

AU - KWONG, Daniel W J

AU - Wong, Chun Yuen

AU - MA, Edmond Dik Lung

PY - 2015/3/7

Y1 - 2015/3/7

N2 - We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. This journal is

AB - We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. This journal is

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DO - 10.1039/c4cc09251a

M3 - Article

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SN - 1359-7345

VL - 51

SP - 3973

EP - 3976

JO - Chemical Communications

JF - Chemical Communications

IS - 19

ER -

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

Abstract

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