@article{fb22eb17bc7b442eb93550cf6fa4e3eb,
title = "A metal-based tumour necrosis factor-alpha converting enzyme inhibitor",
abstract = "We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.",
author = "Leung, {Chung Hang} and Liu, {Li Juan} and Lihua Lu and Bingyong He and Kwong, {Daniel W.J.} and Wong, {Chun Yuen} and Ma, {Dik Lung}",
note = "This work is supported by Hong Kong Baptist University (FRG2/13-14/008), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/13121482), the Research Grants Council (HKBU/201811, HKBU/204612, and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), the Science and Technology Development Fund, Macao SAR (103/2012/A3) and the University of Macau (MYRG091(Y3-L2)-ICMS12-LCH, MYRG121(Y3-L2)-ICMS12-LCH and MRG023/LCH/2013/ICMS).",
year = "2015",
month = mar,
day = "7",
doi = "10.1039/c4cc09251a",
language = "English",
volume = "51",
pages = "3973--3976",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "19",
}