A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

Chung Hang Leung*, Li Juan Liu, Lihua Lu, Bingyong He, Daniel W J KWONG, Chun Yuen Wong, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

25 Citations (Scopus)


We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. This journal is

Original languageEnglish
Pages (from-to)3973-3976
Number of pages4
JournalChemical Communications
Issue number19
Publication statusPublished - 7 Mar 2015

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


Dive into the research topics of 'A metal-based tumour necrosis factor-alpha converting enzyme inhibitor'. Together they form a unique fingerprint.

Cite this