Abstract
We report herein a novel iridium(iii) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. This journal is
Original language | English |
---|---|
Pages (from-to) | 3973-3976 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 51 |
Issue number | 19 |
DOIs | |
Publication status | Published - 7 Mar 2015 |
Scopus Subject Areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry