@article{ba11de1d70c449ebb48f349e4b7b1cae,
title = "A metal-based inhibitor of tumor necrosis factor-α",
abstract = "Staying in the pocket: A cyclometalated iridium(III) biquinoline complex targets the protein-protein interface (see picture; C yellow, N blue, Ir dark green) of the tumor necrosis factor-α (TNF-α) trimer. Molecular-modeling studies confirm the nature of this interaction. Both enantiomers of the iridium complex display comparable in vitro potency to the strongest small-molecule inhibitor of TNF-α.",
keywords = "inhibitors, iridium(III) complexes, metal-based inhibitors, protein-protein interactions, tumor necrosis factor",
author = "Leung, {Chung Hang} and Zhong, {Hai Jing} and Hui Yang and Zhen Cheng and Chan, {Daniel Shiu Hin} and Ma, {Victor Pui Yan} and Ruben Abagyan and Wong, {Chun Yuen} and Ma, {Dik Lung}",
note = "his work is supported by Hong Kong Baptist University (FRG2/10-11/008 and FRG2/11-12/009), Environment and Conservation Fund(ECF Project 3/2010), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Research Fund for the Control of Infectious Diseases (RFCID/11101212), the Research Grants Council (HKBU/201811), and the University of Macau (Start-up Research Grant to C.-H. Leung), MYRG091(Y1-L2)-ICMS12-LCH and MYRG121(Y1-L2)-ICMS12-LCH). ",
year = "2012",
month = sep,
day = "3",
doi = "10.1002/anie.201202937",
language = "English",
volume = "51",
pages = "9010--9014",
journal = "Angewandte Chemie. International Edition",
issn = "1433-7851",
publisher = "John Wiley & Sons Ltd.",
number = "36",
}