A metal-based inhibitor of tumor necrosis factor-α

Chung Hang Leung*, Hai Jing Zhong, Hui Yang, Zhen Cheng, Daniel Shiu Hin Chan, Victor Pui Yan Ma, Ruben Abagyan, Chun Yuen Wong, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

140 Citations (Scopus)

Abstract

Staying in the pocket: A cyclometalated iridium(III) biquinoline complex targets the protein-protein interface (see picture; C yellow, N blue, Ir dark green) of the tumor necrosis factor-α (TNF-α) trimer. Molecular-modeling studies confirm the nature of this interaction. Both enantiomers of the iridium complex display comparable in vitro potency to the strongest small-molecule inhibitor of TNF-α.

Original languageEnglish
Pages (from-to)9010-9014
Number of pages5
JournalAngewandte Chemie. International Edition
Volume51
Issue number36
DOIs
Publication statusPublished - 3 Sep 2012

Scopus Subject Areas

  • Catalysis
  • Chemistry(all)

User-Defined Keywords

  • inhibitors
  • iridium(III) complexes
  • metal-based inhibitors
  • protein-protein interactions
  • tumor necrosis factor

Fingerprint

Dive into the research topics of 'A metal-based inhibitor of tumor necrosis factor-α'. Together they form a unique fingerprint.

Cite this