Abstract
Staying in the pocket: A cyclometalated iridium(III) biquinoline complex targets the protein-protein interface (see picture; C yellow, N blue, Ir dark green) of the tumor necrosis factor-α (TNF-α) trimer. Molecular-modeling studies confirm the nature of this interaction. Both enantiomers of the iridium complex display comparable in vitro potency to the strongest small-molecule inhibitor of TNF-α.
Original language | English |
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Pages (from-to) | 9010-9014 |
Number of pages | 5 |
Journal | Angewandte Chemie. International Edition |
Volume | 51 |
Issue number | 36 |
DOIs | |
Publication status | Published - 3 Sept 2012 |
Scopus Subject Areas
- Catalysis
- Chemistry(all)
User-Defined Keywords
- inhibitors
- iridium(III) complexes
- metal-based inhibitors
- protein-protein interactions
- tumor necrosis factor