A Metabolic Driven Bio-Responsive Hydrogel Loading Psoralen for Therapy of Rheumatoid Arthritis

Kexin Wang*, Chuanhui Yin, Xiangmin Ye, Quanlin Chen, Jie Wu, Yupeng Chen, Yi Li, Jun Wang, Chuanzhi Duan, Aiping Lu*, Daogang Guan*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

2 Citations (Scopus)

Abstract

Overexpressed matrix metalloproteinases, hypoxia microenvironment, and metabolic abnormality are important pathological signs of rheumatoid arthritis (RA). Designing a delivery carrier according to the pathological characteristics of RA that can control drug release in response to disease severity may be a promising treatment strategy. Psoralen is the main active ingredient isolated from Psoralea corylifolia L. and possesses excellent anti-inflammatory activities as well as improving bone homeostasis. However, the specific underlying mechanisms, particularly the possible relationships between the anti-RA effects of psoralen and related metabolic network, remain largely unexplored. Furthermore, psoralen shows systemic side effects and has unsatisfactory solubility. Therefore, it is desirable to develop a novel delivery system to maximize psoralen's therapeutic effect. In this study, a self-assembled degradable hydrogel platform is developed that delivers psoralen and calcium peroxide to arthritic joints and controls the release of psoralen and oxygen according to inflammatory stimulation, to regulate homeostasis and the metabolic disorder of the anoxic arthritic microenvironment. Therefore, the hydrogel drug delivery system based on the responsiveness of the inflammatory microenvironment and regulation of metabolism provides a new therapeutic strategy for RA treatment.

Original languageEnglish
Article number2207319
JournalSmall
Volume19
Issue number21
Early online date4 Mar 2023
DOIs
Publication statusPublished - 24 May 2023

Scopus Subject Areas

  • Biotechnology
  • Chemistry(all)
  • Biomaterials
  • Materials Science(all)
  • Engineering (miscellaneous)

User-Defined Keywords

  • delivery system
  • metabolic-driven
  • psoralen
  • rheumatoid arthritis

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