A mechanosensitive cation channel in endothelial cells

Xiaoqiang Yao*, Hiu Yee Kwan, Yu Huang

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

7 Citations (Scopus)

Abstract

A mechanosensitive Ca2+-permeable channel is present in vascular endothelial cells. The activity of this channel increases in response to hemodynamic blood flow. Recently, it has been found that the activity of this channel may be regulated by cGMP through a protein kinase G-dependent pathway. Inhibition of the channel by cGMP abolishes the Ca2+ influx elicited by flow. Several inhibitors of the cation channel including Gd3+, Ni2+, and SK&F-96365 also inhibit the Ca2+ influx due to flow stimulation. These data suggest that a mechanosensitive cation channel is the primary pathway mediating the flow-induced Ca2+ entry in vascular endothelial cells.

Original languageEnglish
Pages (from-to)340-341
Number of pages2
JournalJournal of Cardiac Surgery
Volume17
Issue number4
DOIs
Publication statusPublished - 12 Jul 2001

Scopus Subject Areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'A mechanosensitive cation channel in endothelial cells'. Together they form a unique fingerprint.

Cite this