A mechanosensitive cation channel in endothelial cells

Xiaoqiang Yao; Hiu Yee Kwan; Yu Huang

doi:10.1111/j.1540-8191.2001.tb01154.x

A mechanosensitive cation channel in endothelial cells

Xiaoqiang Yao^*, Hiu Yee Kwan, Yu Huang

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

8 Citations (Scopus)

Abstract

A mechanosensitive Ca²⁺-permeable channel is present in vascular endothelial cells. The activity of this channel increases in response to hemodynamic blood flow. Recently, it has been found that the activity of this channel may be regulated by cGMP through a protein kinase G-dependent pathway. Inhibition of the channel by cGMP abolishes the Ca²⁺ influx elicited by flow. Several inhibitors of the cation channel including Gd³⁺, Ni²⁺, and SK&F-96365 also inhibit the Ca²⁺ influx due to flow stimulation. These data suggest that a mechanosensitive cation channel is the primary pathway mediating the flow-induced Ca²⁺ entry in vascular endothelial cells.

Original language	English
Pages (from-to)	340-341
Number of pages	2
Journal	Journal of Cardiac Surgery
Volume	17
Issue number	4
DOIs	https://doi.org/10.1111/j.1540-8191.2001.tb01154.x
Publication status	Published - 12 Jul 2001

Scopus Subject Areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

Access to Document

10.1111/j.1540-8191.2001.tb01154.x

Cite this

@article{6d439bca1d0f449393d6fb5aa0261685,

title = "A mechanosensitive cation channel in endothelial cells",

abstract = "A mechanosensitive Ca2+-permeable channel is present in vascular endothelial cells. The activity of this channel increases in response to hemodynamic blood flow. Recently, it has been found that the activity of this channel may be regulated by cGMP through a protein kinase G-dependent pathway. Inhibition of the channel by cGMP abolishes the Ca2+ influx elicited by flow. Several inhibitors of the cation channel including Gd3+, Ni2+, and SK&F-96365 also inhibit the Ca2+ influx due to flow stimulation. These data suggest that a mechanosensitive cation channel is the primary pathway mediating the flow-induced Ca2+ entry in vascular endothelial cells.",

author = "Xiaoqiang Yao and Kwan, {Hiu Yee} and Yu Huang",

year = "2001",

month = jul,

day = "12",

doi = "10.1111/j.1540-8191.2001.tb01154.x",

language = "English",

volume = "17",

pages = "340--341",

journal = "Journal of Cardiac Surgery",

issn = "0886-0440",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "4",

}

TY - JOUR

T1 - A mechanosensitive cation channel in endothelial cells

AU - Yao, Xiaoqiang

AU - Kwan, Hiu Yee

AU - Huang, Yu

PY - 2001/7/12

Y1 - 2001/7/12

N2 - A mechanosensitive Ca2+-permeable channel is present in vascular endothelial cells. The activity of this channel increases in response to hemodynamic blood flow. Recently, it has been found that the activity of this channel may be regulated by cGMP through a protein kinase G-dependent pathway. Inhibition of the channel by cGMP abolishes the Ca2+ influx elicited by flow. Several inhibitors of the cation channel including Gd3+, Ni2+, and SK&F-96365 also inhibit the Ca2+ influx due to flow stimulation. These data suggest that a mechanosensitive cation channel is the primary pathway mediating the flow-induced Ca2+ entry in vascular endothelial cells.

AB - A mechanosensitive Ca2+-permeable channel is present in vascular endothelial cells. The activity of this channel increases in response to hemodynamic blood flow. Recently, it has been found that the activity of this channel may be regulated by cGMP through a protein kinase G-dependent pathway. Inhibition of the channel by cGMP abolishes the Ca2+ influx elicited by flow. Several inhibitors of the cation channel including Gd3+, Ni2+, and SK&F-96365 also inhibit the Ca2+ influx due to flow stimulation. These data suggest that a mechanosensitive cation channel is the primary pathway mediating the flow-induced Ca2+ entry in vascular endothelial cells.

UR - http://www.scopus.com/inward/record.url?scp=0036665118&partnerID=8YFLogxK

U2 - 10.1111/j.1540-8191.2001.tb01154.x

DO - 10.1111/j.1540-8191.2001.tb01154.x

M3 - Journal article

C2 - 12546083

SN - 0886-0440

VL - 17

SP - 340

EP - 341

JO - Journal of Cardiac Surgery

JF - Journal of Cardiac Surgery

IS - 4

ER -

A mechanosensitive cation channel in endothelial cells

Abstract

Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this