A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Yu Man Ho, Ngan Pan Bennett Au, Ka-Leung WONG, Chris Tsz-Leung Chan, Wai Ming Kwok, Ga Lai Law, Kwong Kit Tang, Wai Yeung WONG, Chi Him Eddie Ma*, Michael Hon-Wah Lam

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, ([Pt(L1)]2(μ-dppm))2+ (1) and ([Pt(L2)]2(μ-dppm))2+ (2), as lysosome-specific two-photon imaging probes.

Original languageEnglish
Pages (from-to)4161-4163
Number of pages3
JournalChemical Communications
Volume50
Issue number32
DOIs
Publication statusPublished - 25 Mar 2014

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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