A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Yu Man Ho; Ngan Pan Bennett Au; Ka-Leung WONG; Chris Tsz-Leung Chan; Wai Ming Kwok; Ga Lai Law; Kwong Kit Tang; Wai Yeung WONG; Chi Him Eddie Ma; Michael Hon-Wah Lam

doi:10.1039/c3cc48934e

A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Yu Man Ho, Ngan Pan Bennett Au, Ka-Leung WONG, Chris Tsz-Leung Chan, Wai Ming Kwok, Ga Lai Law, Kwong Kit Tang, Wai Yeung WONG, Chi Him Eddie Ma^*, Michael Hon-Wah Lam

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, ([Pt(L₁)]₂(μ-dppm))²⁺ (1) and ([Pt(L₂)]₂(μ-dppm))²⁺ (2), as lysosome-specific two-photon imaging probes.

Original language	English
Pages (from-to)	4161-4163
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	32
DOIs	https://doi.org/10.1039/c3cc48934e
Publication status	Published - 25 Mar 2014

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons",

abstract = "Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, ([Pt(L1)]2(μ-dppm))2+ (1) and ([Pt(L2)]2(μ-dppm))2+ (2), as lysosome-specific two-photon imaging probes.",

author = "Ho, {Yu Man} and {Bennett Au}, {Ngan Pan} and Ka-Leung WONG and {Tsz-Leung Chan}, Chris and Kwok, {Wai Ming} and Law, {Ga Lai} and Tang, {Kwong Kit} and WONG, {Wai Yeung} and {Eddie Ma}, {Chi Him} and {Hon-Wah Lam}, Michael",

year = "2014",

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doi = "10.1039/c3cc48934e",

language = "English",

volume = "50",

pages = "4161--4163",

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publisher = "Royal Society of Chemistry",

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T1 - A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

AU - Ho, Yu Man

AU - Bennett Au, Ngan Pan

AU - WONG, Ka-Leung

AU - Tsz-Leung Chan, Chris

AU - Kwok, Wai Ming

AU - Law, Ga Lai

AU - Tang, Kwong Kit

AU - WONG, Wai Yeung

AU - Eddie Ma, Chi Him

AU - Hon-Wah Lam, Michael

PY - 2014/3/25

Y1 - 2014/3/25

N2 - Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, ([Pt(L1)]2(μ-dppm))2+ (1) and ([Pt(L2)]2(μ-dppm))2+ (2), as lysosome-specific two-photon imaging probes.

AB - Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, ([Pt(L1)]2(μ-dppm))2+ (1) and ([Pt(L2)]2(μ-dppm))2+ (2), as lysosome-specific two-photon imaging probes.

UR - http://www.scopus.com/inward/record.url?scp=84897008214&partnerID=8YFLogxK

U2 - 10.1039/c3cc48934e

DO - 10.1039/c3cc48934e

M3 - Article

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AN - SCOPUS:84897008214

SN - 1359-7345

VL - 50

SP - 4161

EP - 4163

JO - Chemical Communications

JF - Chemical Communications

IS - 32

ER -

A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons

Abstract

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