A luminescent G-quadruplex switch-on probe for the highly selective and tunable detection of cysteine and glutathione

Ka Ho Leung; Hong Zhang He; Victor Pui Yan Ma; Daniel Shiu Hin Chan; Chung Hang Leung; Dik Lung Ma

doi:10.1039/c2cc37710a

A luminescent G-quadruplex switch-on probe for the highly selective and tunable detection of cysteine and glutathione

Ka Ho Leung
, Hong Zhang He
, Victor Pui Yan Ma
, Daniel Shiu Hin Chan
, Chung Hang Leung^*
, Dik Lung Ma

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

97 Citations (Scopus)

Abstract

A G-quadruplex-selective luminescent iridium(III) switch-on probe has been developed for the detection of cysteine (Cys) in aqueous solution. The system is highly sensitive and selective towards Cys with a tunable range of detection. The detection of glutathione (GSH) is also examined.

Original language	English
Pages (from-to)	771-773
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	8
DOIs	https://doi.org/10.1039/c2cc37710a
Publication status	Published - 28 Jan 2013

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title = "A luminescent G-quadruplex switch-on probe for the highly selective and tunable detection of cysteine and glutathione",

abstract = "A G-quadruplex-selective luminescent iridium(III) switch-on probe has been developed for the detection of cysteine (Cys) in aqueous solution. The system is highly sensitive and selective towards Cys with a tunable range of detection. The detection of glutathione (GSH) is also examined.",

author = "Leung, \{Ka Ho\} and He, \{Hong Zhang\} and Ma, \{Victor Pui Yan\} and Chan, \{Daniel Shiu Hin\} and Leung, \{Chung Hang\} and Ma, \{Dik Lung\}",

note = "This work is supported by Hong Kong Baptist University (FRG2/11-12/009), Environment and Conservation Fund (ECF Project 3/2010), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/11101212), the Research Grants Council (HKBU/201811 and HKBU/204612), the Science and Technology Development Fund, Macao SAR (001/2012/A) and the University of Macau (SRG013-ICMS12-LCH, MYRG091(Y1-L2)-ICMS12-LCH and MYRG121(Y1-L2)-ICMS12-LCH).",

year = "2013",

month = jan,

day = "28",

doi = "10.1039/c2cc37710a",

language = "English",

volume = "49",

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journal = "Chemical Communications",

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T1 - A luminescent G-quadruplex switch-on probe for the highly selective and tunable detection of cysteine and glutathione

AU - Leung, Ka Ho

AU - He, Hong Zhang

AU - Ma, Victor Pui Yan

AU - Chan, Daniel Shiu Hin

AU - Leung, Chung Hang

AU - Ma, Dik Lung

N1 - This work is supported by Hong Kong Baptist University (FRG2/11-12/009), Environment and Conservation Fund (ECF Project 3/2010), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/11101212), the Research Grants Council (HKBU/201811 and HKBU/204612), the Science and Technology Development Fund, Macao SAR (001/2012/A) and the University of Macau (SRG013-ICMS12-LCH, MYRG091(Y1-L2)-ICMS12-LCH and MYRG121(Y1-L2)-ICMS12-LCH).

PY - 2013/1/28

Y1 - 2013/1/28

N2 - A G-quadruplex-selective luminescent iridium(III) switch-on probe has been developed for the detection of cysteine (Cys) in aqueous solution. The system is highly sensitive and selective towards Cys with a tunable range of detection. The detection of glutathione (GSH) is also examined.

AB - A G-quadruplex-selective luminescent iridium(III) switch-on probe has been developed for the detection of cysteine (Cys) in aqueous solution. The system is highly sensitive and selective towards Cys with a tunable range of detection. The detection of glutathione (GSH) is also examined.

UR - https://www.scopus.com/pages/publications/84871753500

U2 - 10.1039/c2cc37710a

DO - 10.1039/c2cc37710a

M3 - Journal article

C2 - 23192322

AN - SCOPUS:84871753500

SN - 1359-7345

VL - 49

SP - 771

EP - 773

JO - Chemical Communications

JF - Chemical Communications

IS - 8

ER -

A luminescent G-quadruplex switch-on probe for the highly selective and tunable detection of cysteine and glutathione

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