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A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(III)-based i-motif probe

  • Lihua Lu
  • , Modi Wang
  • , Li Juan Liu
  • , Chun Yuen Wong
  • , Chung Hang Leung*
  • , Edmond Dik Lung Ma*
  • *Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

67 Citations (Scopus)

Abstract

An iridium(III) complex exhibiting higher responce towards i-motif DNA over dsDNA and ssDNA was employed for the construction of a TdT activity detection platform. The assay exhibited a linear signal enhancement for TdT in the concentration range of 0 to 8 U mL-1, and the limit of detection for TdT was 0.25 U mL-1.

Original languageEnglish
Pages (from-to)9953-9956
Number of pages4
JournalChemical Communications
Volume51
Issue number49
DOIs
Publication statusPublished - 21 Jun 2015

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