@article{e4ce4968194c4a968699d6fc60abe779,
title = "A long-lived phosphorescence iridium(III) complex as a switch on-off-on probe for live zebrafish monitoring of endogenous sulfide generation",
abstract = "In this work, we report a novel iridium(III)-based luminescent switch on-off-on probe, for the in vitro and in vivo detection of sulfide ion. The mechanism of this platform is based on the effective charge transfer quenching of the iridium(III) complex 1 by Fe3+, followed by the restoration of luminescence upon the addition of Na2S. The probe, hereinafter referred to as 1–Fe3+, exhibited a linear range of detection for Na2S from 0.01 to 1.5 mM, with a detection limit of 2.9 μM at signal-to-noise ratio (S/N) of 3. We also demonstrate the utility of 1–Fe3+ for cell-based imaging as well as for the detection of enzymatic sulfide generation in living zebrafish.",
keywords = "Endogenous sulfide production, Iridum(III) complex, Sulfide detection in living organism",
author = "Ko, \{Chung Nga\} and Chao Yang and Sheng Lin and Shengnan Li and Zhenzhen Dong and Jinbiao Liu and Lee, \{Simon Ming Yuen\} and Leung, \{Chung Hang\} and Ma, \{Edmond Dik Lung\}",
note = "Funding Information: This work is supported by the National Natural Science Foundation of China (Nos. 21502075 and 21575121), Hong Kong Baptist University (FRG2/16-17/007), the Health and Medical Research Fund (HMRF/14-15/02CHEM), the Research Grants Council (HKBU12301115), the State Key Laboratory of Environmental and Biological Analysis Research Grant (SKLP-14?15-P001), the Science and Technology Development Fund, Macao SAR (098/2014/A2) and the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM and MRG044/LCH/2015/ICMS).",
year = "2017",
month = aug,
day = "15",
doi = "10.1016/j.bios.2017.03.050",
language = "English",
volume = "94",
pages = "575--583",
journal = "Biosensors and Bioelectronics",
issn = "0956-5663",
publisher = "Elsevier Ltd.",
}