A long-lived iridium(iii) chemosensor for the real-time detection of GHB

Wanhe Wang; Zhen Zhen Dong; Guanjun Yang; Chung Hang Leung; Sheng Lin; Edmond Dik Lung MA

doi:10.1039/C6TB03396B

A long-lived iridium(iii) chemosensor for the real-time detection of GHB

Wanhe Wang, Zhen Zhen Dong, Guanjun Yang, Chung Hang Leung, Sheng Lin^*, Edmond Dik Lung MA

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Gamma-hydroxybutyric acid (GHB) is a commonly used “date rape” drug in drug-facilitated sexual assaults (DFSA) due to its low price and ready availability, and it is more quickly excreted from the human body than other drugs. Therefore, the development of a real-time detection method for GHB could help facilitate law enforcement agencies in tackling DFSA. In this work, a long-lived iridium(iii) chemosensor 1 has been synthesized for the switch-off detection of GHB. Upon addition of GHB to an aqueous solution of the iridium(iii) complex 1, a significant luminescence quenching occurred that could be observed by the naked eye under UV illumination. The luminescence signal of the iridium(iii) complex 1 could also be distinguished from strongly fluorescent media using time-resolved emission spectroscopy.

Original language	English
Pages (from-to)	2739-2742
Number of pages	4
Journal	Journal of Materials Chemistry B
Volume	5
Issue number	15
DOIs	https://doi.org/10.1039/C6TB03396B
Publication status	Published - 2017

Scopus Subject Areas

Chemistry(all)
Biomedical Engineering
Materials Science(all)

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title = "A long-lived iridium(iii) chemosensor for the real-time detection of GHB",

abstract = "Gamma-hydroxybutyric acid (GHB) is a commonly used “date rape” drug in drug-facilitated sexual assaults (DFSA) due to its low price and ready availability, and it is more quickly excreted from the human body than other drugs. Therefore, the development of a real-time detection method for GHB could help facilitate law enforcement agencies in tackling DFSA. In this work, a long-lived iridium(iii) chemosensor 1 has been synthesized for the switch-off detection of GHB. Upon addition of GHB to an aqueous solution of the iridium(iii) complex 1, a significant luminescence quenching occurred that could be observed by the naked eye under UV illumination. The luminescence signal of the iridium(iii) complex 1 could also be distinguished from strongly fluorescent media using time-resolved emission spectroscopy.",

author = "Wanhe Wang and Dong, {Zhen Zhen} and Guanjun Yang and Leung, {Chung Hang} and Sheng Lin and MA, {Edmond Dik Lung}",

note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/ 15-16/002), the Health and Medical Research Fund (HMRF/ 14130522), the Research Grants Council (HKBU/12301115, HKBU/204612 and HKBU/201913), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme (AHKBU201/12; Oligoswitch ANR-12-IS07-0001), the National Natural Science Foundation of China (21575121 and 21628502), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2016, the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Science and Technology Development Fund,Macao SAR (007/2014/AMJ and 077/2016/A2), the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMSQRCM and MRG044/LCH/2015/ICMS).",

year = "2017",

doi = "10.1039/C6TB03396B",

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publisher = "Royal Society of Chemistry",

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T1 - A long-lived iridium(iii) chemosensor for the real-time detection of GHB

AU - Wang, Wanhe

AU - Dong, Zhen Zhen

AU - Yang, Guanjun

AU - Leung, Chung Hang

AU - Lin, Sheng

AU - MA, Edmond Dik Lung

N1 - Funding Information: This work is supported by Hong Kong Baptist University (FRG2/ 15-16/002), the Health and Medical Research Fund (HMRF/ 14130522), the Research Grants Council (HKBU/12301115, HKBU/204612 and HKBU/201913), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme (AHKBU201/12; Oligoswitch ANR-12-IS07-0001), the National Natural Science Foundation of China (21575121 and 21628502), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2016, the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Science and Technology Development Fund,Macao SAR (007/2014/AMJ and 077/2016/A2), the University of Macau (MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMSQRCM and MRG044/LCH/2015/ICMS).

PY - 2017

Y1 - 2017

N2 - Gamma-hydroxybutyric acid (GHB) is a commonly used “date rape” drug in drug-facilitated sexual assaults (DFSA) due to its low price and ready availability, and it is more quickly excreted from the human body than other drugs. Therefore, the development of a real-time detection method for GHB could help facilitate law enforcement agencies in tackling DFSA. In this work, a long-lived iridium(iii) chemosensor 1 has been synthesized for the switch-off detection of GHB. Upon addition of GHB to an aqueous solution of the iridium(iii) complex 1, a significant luminescence quenching occurred that could be observed by the naked eye under UV illumination. The luminescence signal of the iridium(iii) complex 1 could also be distinguished from strongly fluorescent media using time-resolved emission spectroscopy.

AB - Gamma-hydroxybutyric acid (GHB) is a commonly used “date rape” drug in drug-facilitated sexual assaults (DFSA) due to its low price and ready availability, and it is more quickly excreted from the human body than other drugs. Therefore, the development of a real-time detection method for GHB could help facilitate law enforcement agencies in tackling DFSA. In this work, a long-lived iridium(iii) chemosensor 1 has been synthesized for the switch-off detection of GHB. Upon addition of GHB to an aqueous solution of the iridium(iii) complex 1, a significant luminescence quenching occurred that could be observed by the naked eye under UV illumination. The luminescence signal of the iridium(iii) complex 1 could also be distinguished from strongly fluorescent media using time-resolved emission spectroscopy.

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JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

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ER -

A long-lived iridium(iii) chemosensor for the real-time detection of GHB

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