A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift

Jin Biao Liu; Kasipandi Vellaisamy; Guodong Li; Chao Yang; Suk Yu Wong; Chung Hang Leung; Shou Zhi Pu; Dik Lung Ma

doi:10.1039/c8tb00666k

A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift

Jin Biao Liu, Kasipandi Vellaisamy, Guodong Li, Chao Yang, Suk Yu Wong, Chung Hang Leung, Shou Zhi Pu^*, Dik Lung Ma

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

23 Citations (Scopus)

Abstract

Investigating the role of lysosome dysfunction in cancer requires the development of efficient probes for lysosomes. We report herein a cyclometalated iridium(iii) complex (Ir-Ly) as a luminescent probe for visualizing lysosomes in cancer cells. The morpholine and hydroxy moieties within Ir-Ly provide suitable hydrophilicity and responsiveness to pH. Importantly, Ir-Ly exhibits a large Stokes shift, long lifetime and high photostability, which are important advantages for lysosome tracking in living cells.

Original language	English
Pages (from-to)	3855-3858
Number of pages	4
Journal	Journal of Materials Chemistry B
Volume	6
Issue number	23
DOIs	https://doi.org/10.1039/c8tb00666k
Publication status	Published - 2018

Scopus Subject Areas

General Chemistry
Biomedical Engineering
General Materials Science

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@article{7afe0b9b562b4cdcb0bab3e9f8f8be7a,

title = "A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift",

abstract = "Investigating the role of lysosome dysfunction in cancer requires the development of efficient probes for lysosomes. We report herein a cyclometalated iridium(iii) complex (Ir-Ly) as a luminescent probe for visualizing lysosomes in cancer cells. The morpholine and hydroxy moieties within Ir-Ly provide suitable hydrophilicity and responsiveness to pH. Importantly, Ir-Ly exhibits a large Stokes shift, long lifetime and high photostability, which are important advantages for lysosome tracking in living cells.",

author = "Liu, {Jin Biao} and Kasipandi Vellaisamy and Guodong Li and Chao Yang and Wong, {Suk Yu} and Leung, {Chung Hang} and Pu, {Shou Zhi} and Ma, {Dik Lung}",

note = "Funding Information: This work is supported by Hong Kong Baptist University (FRG2/16-17/007 and FRG2/17-18/003), the Health and Medical Research Fund (HMRF/14150561), the Research Grants Council (HKBU/12301115), the National Natural Science Foundation of China (21575121, 21775131, 21628502, 21502075 and 21762018), the Postdoctoral Science Foundation of Jiangxi Province (2017KY22), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2017, the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03 and RC-IRMS/ 16-17/03), Innovation and Technology Fund (ITS/260/16FX), Collaborative Research Fund (C5026-16G), Matching Proof of Concept Fund (MPCF-001-2017/18), the Science and Technology Development Fund, Macao SAR (098/2014/A2), the University of Macau (MYRG2016-00151-ICMS-QRCM and MRG044/LCH/ 2015/ICMS), and the Natural Science Foundation of Jiangxi Province (20171BAB213008).",

year = "2018",

doi = "10.1039/c8tb00666k",

language = "English",

volume = "6",

pages = "3855--3858",

journal = "Journal of Materials Chemistry B",

issn = "2050-750X",

publisher = "Royal Society of Chemistry",

number = "23",

}

TY - JOUR

T1 - A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift

AU - Liu, Jin Biao

AU - Vellaisamy, Kasipandi

AU - Li, Guodong

AU - Yang, Chao

AU - Wong, Suk Yu

AU - Leung, Chung Hang

AU - Pu, Shou Zhi

AU - Ma, Dik Lung

N1 - Funding Information: This work is supported by Hong Kong Baptist University (FRG2/16-17/007 and FRG2/17-18/003), the Health and Medical Research Fund (HMRF/14150561), the Research Grants Council (HKBU/12301115), the National Natural Science Foundation of China (21575121, 21775131, 21628502, 21502075 and 21762018), the Postdoctoral Science Foundation of Jiangxi Province (2017KY22), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2017, the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03 and RC-IRMS/ 16-17/03), Innovation and Technology Fund (ITS/260/16FX), Collaborative Research Fund (C5026-16G), Matching Proof of Concept Fund (MPCF-001-2017/18), the Science and Technology Development Fund, Macao SAR (098/2014/A2), the University of Macau (MYRG2016-00151-ICMS-QRCM and MRG044/LCH/ 2015/ICMS), and the Natural Science Foundation of Jiangxi Province (20171BAB213008).

PY - 2018

Y1 - 2018

N2 - Investigating the role of lysosome dysfunction in cancer requires the development of efficient probes for lysosomes. We report herein a cyclometalated iridium(iii) complex (Ir-Ly) as a luminescent probe for visualizing lysosomes in cancer cells. The morpholine and hydroxy moieties within Ir-Ly provide suitable hydrophilicity and responsiveness to pH. Importantly, Ir-Ly exhibits a large Stokes shift, long lifetime and high photostability, which are important advantages for lysosome tracking in living cells.

AB - Investigating the role of lysosome dysfunction in cancer requires the development of efficient probes for lysosomes. We report herein a cyclometalated iridium(iii) complex (Ir-Ly) as a luminescent probe for visualizing lysosomes in cancer cells. The morpholine and hydroxy moieties within Ir-Ly provide suitable hydrophilicity and responsiveness to pH. Importantly, Ir-Ly exhibits a large Stokes shift, long lifetime and high photostability, which are important advantages for lysosome tracking in living cells.

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U2 - 10.1039/c8tb00666k

DO - 10.1039/c8tb00666k

M3 - Journal article

C2 - 32254312

AN - SCOPUS:85048620067

SN - 2050-750X

VL - 6

SP - 3855

EP - 3858

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 23

ER -

A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift

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