A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift

Jin Biao Liu, Kasipandi Vellaisamy, Guodong Li, Chao Yang, Suk Yu Wong, Chung Hang Leung, Shou Zhi Pu*, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Investigating the role of lysosome dysfunction in cancer requires the development of efficient probes for lysosomes. We report herein a cyclometalated iridium(iii) complex (Ir-Ly) as a luminescent probe for visualizing lysosomes in cancer cells. The morpholine and hydroxy moieties within Ir-Ly provide suitable hydrophilicity and responsiveness to pH. Importantly, Ir-Ly exhibits a large Stokes shift, long lifetime and high photostability, which are important advantages for lysosome tracking in living cells.

Original languageEnglish
Pages (from-to)3855-3858
Number of pages4
JournalJournal of Materials Chemistry B
Volume6
Issue number23
DOIs
Publication statusPublished - 2018

Scopus Subject Areas

  • Chemistry(all)
  • Biomedical Engineering
  • Materials Science(all)

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