A long lifetime iridium(III) complex as a sensitive luminescent probe for bisulfite detection in living zebrafish

Jin Biao Liu*, Chao Yang, Chung Nga Ko, Kasipandi Vellaisamy, Binrui Yang, Ming Yuen Lee, Chung Hang Leung, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

A long-lived iridium(III) complex probe Ir_1 for bisulfite detection has been synthesized. The iridium(III) complex probe Ir_1, containing double aldehyde groups in the N^N donor ligand, can react with bisulfite to form an adduct with enhanced luminescence. The interaction of probe Ir_1 with bisulfite was investigated through NMR and emission titration experiments. Upon the addition of bisulfite, probe Ir_1 displayed more than a 4-fold luminescence enhancement, and a detection limit of 0.35 μM was recorded. Probe Ir_1 shows a large Stokes shift (280 nm) and a long-lived luminescence which allows it to be distinguished from autofluorescent media through time-resolved emission spectroscopy (TRES). Finally, the applications of probe Ir_1 to the detection of bisulfite in living cells and zebrafish were described.

Original languageEnglish
Pages (from-to)971-976
Number of pages6
JournalSensors and Actuators, B: Chemical
Volume243
DOIs
Publication statusPublished - 2017

Scopus Subject Areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

User-Defined Keywords

  • Bisulfite
  • Iridium(III) complex
  • Luminescence
  • Probe

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