@article{e62d5f7a76374487b914fce6c3b8e6a6,
title = "A long lifetime iridium(III) complex as a sensitive luminescent probe for bisulfite detection in living zebrafish",
abstract = "A long-lived iridium(III) complex probe Ir_1 for bisulfite detection has been synthesized. The iridium(III) complex probe Ir_1, containing double aldehyde groups in the N^N donor ligand, can react with bisulfite to form an adduct with enhanced luminescence. The interaction of probe Ir_1 with bisulfite was investigated through NMR and emission titration experiments. Upon the addition of bisulfite, probe Ir_1 displayed more than a 4-fold luminescence enhancement, and a detection limit of 0.35 μM was recorded. Probe Ir_1 shows a large Stokes shift (280 nm) and a long-lived luminescence which allows it to be distinguished from autofluorescent media through time-resolved emission spectroscopy (TRES). Finally, the applications of probe Ir_1 to the detection of bisulfite in living cells and zebrafish were described.",
keywords = "Bisulfite, Iridium(III) complex, Luminescence, Probe",
author = "Liu, {Jin Biao} and Chao Yang and Ko, {Chung Nga} and Kasipandi Vellaisamy and Binrui Yang and Lee, {Ming Yuen} and Leung, {Chung Hang} and Ma, {Edmond Dik Lung}",
note = "This work is supported by Hong Kong Baptist University (FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU 12301115, HKBU/204612 and HKBU/201913), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme (AHKBU201/12; Oligoswitch ANR-12-IS07-0001), the National Natural Science Foundation of China (21575121), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2016, the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Science and Technology Development Fund, Macao SAR (098/2014/A2), and MYRG2015-00137-ICMSQRCM, MRG044/LCH/2015/ICMS), opening fund of the State Key Laboratory of Quality Research in Chinese Medicine, University of Macau (No. 006).",
year = "2017",
month = may,
doi = "10.1016/j.snb.2016.12.083",
language = "English",
volume = "243",
pages = "971--976",
journal = "Sensors and Actuators B: Chemical",
issn = "0925-4005",
publisher = "Elsevier B.V.",
}