A long lifetime iridium(III) complex as a sensitive luminescent probe for bisulfite detection in living zebrafish

Jin Biao Liu; Chao Yang; Chung Nga Ko; Kasipandi Vellaisamy; Binrui Yang; Ming Yuen Lee; Chung Hang Leung; Edmond Dik Lung Ma

doi:10.1016/j.snb.2016.12.083

A long lifetime iridium(III) complex as a sensitive luminescent probe for bisulfite detection in living zebrafish

Jin Biao Liu^*, Chao Yang, Chung Nga Ko, Kasipandi Vellaisamy, Binrui Yang, Ming Yuen Lee, Chung Hang Leung, Edmond Dik Lung Ma

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

92 Citations (Scopus)

Abstract

A long-lived iridium(III) complex probe Ir_1 for bisulfite detection has been synthesized. The iridium(III) complex probe Ir_1, containing double aldehyde groups in the N^N donor ligand, can react with bisulfite to form an adduct with enhanced luminescence. The interaction of probe Ir_1 with bisulfite was investigated through NMR and emission titration experiments. Upon the addition of bisulfite, probe Ir_1 displayed more than a 4-fold luminescence enhancement, and a detection limit of 0.35 μM was recorded. Probe Ir_1 shows a large Stokes shift (280 nm) and a long-lived luminescence which allows it to be distinguished from autofluorescent media through time-resolved emission spectroscopy (TRES). Finally, the applications of probe Ir_1 to the detection of bisulfite in living cells and zebrafish were described.

Original language	English
Pages (from-to)	971-976
Number of pages	6
Journal	Sensors and Actuators B: Chemical
Volume	243
DOIs	https://doi.org/10.1016/j.snb.2016.12.083
Publication status	Published - May 2017

Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

User-Defined Keywords

Bisulfite
Iridium(III) complex
Luminescence
Probe

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10.1016/j.snb.2016.12.083

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title = "A long lifetime iridium(III) complex as a sensitive luminescent probe for bisulfite detection in living zebrafish",

abstract = "A long-lived iridium(III) complex probe Ir_1 for bisulfite detection has been synthesized. The iridium(III) complex probe Ir_1, containing double aldehyde groups in the N^N donor ligand, can react with bisulfite to form an adduct with enhanced luminescence. The interaction of probe Ir_1 with bisulfite was investigated through NMR and emission titration experiments. Upon the addition of bisulfite, probe Ir_1 displayed more than a 4-fold luminescence enhancement, and a detection limit of 0.35 μM was recorded. Probe Ir_1 shows a large Stokes shift (280 nm) and a long-lived luminescence which allows it to be distinguished from autofluorescent media through time-resolved emission spectroscopy (TRES). Finally, the applications of probe Ir_1 to the detection of bisulfite in living cells and zebrafish were described.",

keywords = "Bisulfite, Iridium(III) complex, Luminescence, Probe",

author = "Liu, {Jin Biao} and Chao Yang and Ko, {Chung Nga} and Kasipandi Vellaisamy and Binrui Yang and Lee, {Ming Yuen} and Leung, {Chung Hang} and Ma, {Edmond Dik Lung}",

note = "This work is supported by Hong Kong Baptist University (FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU 12301115, HKBU/204612 and HKBU/201913), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme (AHKBU201/12; Oligoswitch ANR-12-IS07-0001), the National Natural Science Foundation of China (21575121), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2016, the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Science and Technology Development Fund, Macao SAR (098/2014/A2), and MYRG2015-00137-ICMSQRCM, MRG044/LCH/2015/ICMS), opening fund of the State Key Laboratory of Quality Research in Chinese Medicine, University of Macau (No. 006).",

year = "2017",

month = may,

doi = "10.1016/j.snb.2016.12.083",

language = "English",

volume = "243",

pages = "971--976",

journal = "Sensors and Actuators B: Chemical",

issn = "0925-4005",

publisher = "Elsevier",

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T1 - A long lifetime iridium(III) complex as a sensitive luminescent probe for bisulfite detection in living zebrafish

AU - Liu, Jin Biao

AU - Yang, Chao

AU - Ko, Chung Nga

AU - Vellaisamy, Kasipandi

AU - Yang, Binrui

AU - Lee, Ming Yuen

AU - Leung, Chung Hang

AU - Ma, Edmond Dik Lung

N1 - This work is supported by Hong Kong Baptist University (FRG2/15-16/002), the Health and Medical Research Fund (HMRF/14130522), the Research Grants Council (HKBU 12301115, HKBU/204612 and HKBU/201913), the French Agence Nationale de la Recherche/Research Grants Council Joint Research Scheme (AHKBU201/12; Oligoswitch ANR-12-IS07-0001), the National Natural Science Foundation of China (21575121), the Guangdong Province Natural Science Foundation (2015A030313816), the Hong Kong Baptist University Century Club Sponsorship Scheme 2016, the Interdisciplinary Research Matching Scheme (RC-IRMS/15-16/03), the Science and Technology Development Fund, Macao SAR (098/2014/A2), and MYRG2015-00137-ICMSQRCM, MRG044/LCH/2015/ICMS), opening fund of the State Key Laboratory of Quality Research in Chinese Medicine, University of Macau (No. 006).

PY - 2017/5

Y1 - 2017/5

N2 - A long-lived iridium(III) complex probe Ir_1 for bisulfite detection has been synthesized. The iridium(III) complex probe Ir_1, containing double aldehyde groups in the N^N donor ligand, can react with bisulfite to form an adduct with enhanced luminescence. The interaction of probe Ir_1 with bisulfite was investigated through NMR and emission titration experiments. Upon the addition of bisulfite, probe Ir_1 displayed more than a 4-fold luminescence enhancement, and a detection limit of 0.35 μM was recorded. Probe Ir_1 shows a large Stokes shift (280 nm) and a long-lived luminescence which allows it to be distinguished from autofluorescent media through time-resolved emission spectroscopy (TRES). Finally, the applications of probe Ir_1 to the detection of bisulfite in living cells and zebrafish were described.

AB - A long-lived iridium(III) complex probe Ir_1 for bisulfite detection has been synthesized. The iridium(III) complex probe Ir_1, containing double aldehyde groups in the N^N donor ligand, can react with bisulfite to form an adduct with enhanced luminescence. The interaction of probe Ir_1 with bisulfite was investigated through NMR and emission titration experiments. Upon the addition of bisulfite, probe Ir_1 displayed more than a 4-fold luminescence enhancement, and a detection limit of 0.35 μM was recorded. Probe Ir_1 shows a large Stokes shift (280 nm) and a long-lived luminescence which allows it to be distinguished from autofluorescent media through time-resolved emission spectroscopy (TRES). Finally, the applications of probe Ir_1 to the detection of bisulfite in living cells and zebrafish were described.

KW - Bisulfite

KW - Iridium(III) complex

KW - Luminescence

KW - Probe

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U2 - 10.1016/j.snb.2016.12.083

DO - 10.1016/j.snb.2016.12.083

M3 - Journal article

AN - SCOPUS:85006868127

SN - 0925-4005

VL - 243

SP - 971

EP - 976

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

ER -

A long lifetime iridium(III) complex as a sensitive luminescent probe for bisulfite detection in living zebrafish

Abstract

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