A Limit theorem for the replication time of a DNA molecule

Richard Cowan, S. N. Chiu, Lars Holst

Research output: Contribution to journalJournal articlepeer-review


The DNA of higher animals replicates by an interesting mechanism. Enzymes recognise specific sites randomly scattered on the molecule and establish a bidirectional process of unwinding and replication from these sites. We investigate the limiting distribution of the completion time for this process by considering related coverage problems investigated by Janson (1983) and Hall (1988).
Original languageEnglish
Pages (from-to)296-303
Number of pages8
JournalJournal of Applied Probability
Issue number2
Publication statusPublished - Jun 1995

User-Defined Keywords

  • Dna Replication
  • Asymptotics
  • Coverage


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