A Limit theorem for the replication time of a DNA molecule

Richard Cowan; S. N. Chiu; Lars Holst

doi:10.2307/3215289

A Limit theorem for the replication time of a DNA molecule

Richard Cowan, S. N. Chiu, Lars Holst

Department of Mathematics

Research output: Contribution to journal › Journal article › peer-review

Abstract

The DNA of higher animals replicates by an interesting mechanism. Enzymes recognise specific sites randomly scattered on the molecule and establish a bidirectional process of unwinding and replication from these sites. We investigate the limiting distribution of the completion time for this process by considering related coverage problems investigated by Janson (1983) and Hall (1988).

Original language	English
Pages (from-to)	296-303
Number of pages	8
Journal	Journal of Applied Probability
Volume	32
Issue number	2
DOIs	https://doi.org/10.2307/3215289
Publication status	Published - Jun 1995

User-Defined Keywords

Dna Replication
Asymptotics
Coverage

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title = "A Limit theorem for the replication time of a DNA molecule",

abstract = "The DNA of higher animals replicates by an interesting mechanism. Enzymes recognise specific sites randomly scattered on the molecule and establish a bidirectional process of unwinding and replication from these sites. We investigate the limiting distribution of the completion time for this process by considering related coverage problems investigated by Janson (1983) and Hall (1988).",

keywords = "Dna Replication, Asymptotics, Coverage",

author = "Richard Cowan and Chiu, {S. N.} and Lars Holst",

note = "Publisher copyright: Copyright {\textcopyright} Applied Probability Trust 1995",

year = "1995",

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doi = "10.2307/3215289",

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AU - Cowan, Richard

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AU - Holst, Lars

PY - 1995/6

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N2 - The DNA of higher animals replicates by an interesting mechanism. Enzymes recognise specific sites randomly scattered on the molecule and establish a bidirectional process of unwinding and replication from these sites. We investigate the limiting distribution of the completion time for this process by considering related coverage problems investigated by Janson (1983) and Hall (1988).

AB - The DNA of higher animals replicates by an interesting mechanism. Enzymes recognise specific sites randomly scattered on the molecule and establish a bidirectional process of unwinding and replication from these sites. We investigate the limiting distribution of the completion time for this process by considering related coverage problems investigated by Janson (1983) and Hall (1988).

KW - Dna Replication

KW - Asymptotics

KW - Coverage

UR - https://www.cambridge.org/core/journals/journal-of-applied-probability/issue/6A4539690BCFC811F444E379CC1F468B

U2 - 10.2307/3215289

DO - 10.2307/3215289

M3 - Journal article

SN - 0021-9002

VL - 32

SP - 296

EP - 303

JO - Journal of Applied Probability

JF - Journal of Applied Probability

IS - 2

ER -

A Limit theorem for the replication time of a DNA molecule

Abstract

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