A labile iridium(III) complex-based luminogenic probe for the ratiometric detection of dithiocarbamate compounds in living system

Chuankai Lin; Xueliang Wang; Sang Cuo Nao; Jing Wang; Jinbiao Liu; Dik Lung Ma; Wei Guo Zhu; Chung Hang Leung; Wanhe Wang

doi:10.1016/j.snb.2022.133133

A labile iridium(III) complex-based luminogenic probe for the ratiometric detection of dithiocarbamate compounds in living system

Chuankai Lin, Xueliang Wang, Sang Cuo Nao, Jing Wang, Jinbiao Liu^*, Dik Lung Ma, Wei Guo Zhu, Chung Hang Leung^*, Wanhe Wang^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

7 Citations (Scopus)

Abstract

Dithiocarbamate bioactive compounds are extensively used in agriculture and medicine, but traditional methods for the detection of dithiocarbamates are limited by complicated sensing systems and incompatibility with living systems. In this work, we developed an iridium(III) solvento complex (1) for the luminogenic detection of dithiocarbamates. The probe can sensitively detect a range of dithiocarbamates including sodium diethyldithiocarbamate (NDDC), sodium dimethyldithiocarbamate (SDDC) and ammonium pyrrolidinedithiocarbamate (APDC) in aqueous buffer with up to 10.3-fold luminescence enhancement and limits of detection in the submicromolar range. Moreover, the probe has the capacity to detect dithiocarbamates in water and drink samples as well as in the presence of living cells. Importantly, this probe is robust to potential interferent including other coordinative thiols and histidine. This work serves as a good starting point for developing a single molecule-based sensing system for dithiocarbamates, and opens the door for developing new imaging probe for dithiocarbamates.

Original language	English
Article number	133133
Journal	Sensors and Actuators B: Chemical
Volume	378
DOIs	https://doi.org/10.1016/j.snb.2022.133133
Publication status	Published - 1 Mar 2023

Scopus Subject Areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

User-Defined Keywords

Cell imaging
Dithiocarbamates
Iridium(III) solvento complex
Luminogenic detection
Real samples

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10.1016/j.snb.2022.133133

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@article{29baf1affe6e4b90a854f5c2c19ce318,

title = "A labile iridium(III) complex-based luminogenic probe for the ratiometric detection of dithiocarbamate compounds in living system",

abstract = "Dithiocarbamate bioactive compounds are extensively used in agriculture and medicine, but traditional methods for the detection of dithiocarbamates are limited by complicated sensing systems and incompatibility with living systems. In this work, we developed an iridium(III) solvento complex (1) for the luminogenic detection of dithiocarbamates. The probe can sensitively detect a range of dithiocarbamates including sodium diethyldithiocarbamate (NDDC), sodium dimethyldithiocarbamate (SDDC) and ammonium pyrrolidinedithiocarbamate (APDC) in aqueous buffer with up to 10.3-fold luminescence enhancement and limits of detection in the submicromolar range. Moreover, the probe has the capacity to detect dithiocarbamates in water and drink samples as well as in the presence of living cells. Importantly, this probe is robust to potential interferent including other coordinative thiols and histidine. This work serves as a good starting point for developing a single molecule-based sensing system for dithiocarbamates, and opens the door for developing new imaging probe for dithiocarbamates.",

keywords = "Cell imaging, Dithiocarbamates, Iridium(III) solvento complex, Luminogenic detection, Real samples",

author = "Chuankai Lin and Xueliang Wang and Nao, {Sang Cuo} and Jing Wang and Jinbiao Liu and Ma, {Dik Lung} and Zhu, {Wei Guo} and Leung, {Chung Hang} and Wanhe Wang",

note = "This work is supported by the Natural Science Basic Research Program of Shaanxi ( 2021JQ-089 , 2021JQ-092 ), the National Natural Science Foundation of China ( 21961014 , 22101230 ), the Fundamental Research Funds for the Central Universities ( 31020200QD017 , 31020200QD023 ), Shanghai Sailing Program ( 21YF1451200 ), the Natural Science Foundation of Chongqing , China ( cstc2021jcyj-msxmX0659 ), the Guangdong Basic and Applied Basic Research Foundation ( 2021A1515110840 ), the Natural Science Foundation of Jiangxi Province , China ( 20192BCBL23009 ), the Youth Jinggang Scholars Program in Jiangxi Province, Postdoctoral Merit Program of Jiangxi Province ( 2021KY21 ), the Science and Technology Development Fund (Macau SAR, China) ( 0007/2020/A1 , 0020/2022/A1 ), the State Key Laboratory of Quality Research in Chinese Medicine (University of Macau) ( SKL-QRCM(UM)-2020-2022 ), the University of Macau (University of Macau) ( MYRG2019-00002-ICMS , MYRG2020–00017-ICMS ), 2022 Internal Research Grant of SKL-QRCM (University of Macau) ( QRCM-IRG2022-011 ). Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2023",

month = mar,

day = "1",

doi = "10.1016/j.snb.2022.133133",

language = "English",

volume = "378",

journal = "Sensors and Actuators B: Chemical",

issn = "0925-4005",

publisher = "Elsevier",

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TY - JOUR

T1 - A labile iridium(III) complex-based luminogenic probe for the ratiometric detection of dithiocarbamate compounds in living system

AU - Lin, Chuankai

AU - Wang, Xueliang

AU - Nao, Sang Cuo

AU - Wang, Jing

AU - Liu, Jinbiao

AU - Ma, Dik Lung

AU - Zhu, Wei Guo

AU - Leung, Chung Hang

AU - Wang, Wanhe

N1 - This work is supported by the Natural Science Basic Research Program of Shaanxi ( 2021JQ-089 , 2021JQ-092 ), the National Natural Science Foundation of China ( 21961014 , 22101230 ), the Fundamental Research Funds for the Central Universities ( 31020200QD017 , 31020200QD023 ), Shanghai Sailing Program ( 21YF1451200 ), the Natural Science Foundation of Chongqing , China ( cstc2021jcyj-msxmX0659 ), the Guangdong Basic and Applied Basic Research Foundation ( 2021A1515110840 ), the Natural Science Foundation of Jiangxi Province , China ( 20192BCBL23009 ), the Youth Jinggang Scholars Program in Jiangxi Province, Postdoctoral Merit Program of Jiangxi Province ( 2021KY21 ), the Science and Technology Development Fund (Macau SAR, China) ( 0007/2020/A1 , 0020/2022/A1 ), the State Key Laboratory of Quality Research in Chinese Medicine (University of Macau) ( SKL-QRCM(UM)-2020-2022 ), the University of Macau (University of Macau) ( MYRG2019-00002-ICMS , MYRG2020–00017-ICMS ), 2022 Internal Research Grant of SKL-QRCM (University of Macau) ( QRCM-IRG2022-011 ). Publisher Copyright: © 2022 Elsevier B.V.

PY - 2023/3/1

Y1 - 2023/3/1

N2 - Dithiocarbamate bioactive compounds are extensively used in agriculture and medicine, but traditional methods for the detection of dithiocarbamates are limited by complicated sensing systems and incompatibility with living systems. In this work, we developed an iridium(III) solvento complex (1) for the luminogenic detection of dithiocarbamates. The probe can sensitively detect a range of dithiocarbamates including sodium diethyldithiocarbamate (NDDC), sodium dimethyldithiocarbamate (SDDC) and ammonium pyrrolidinedithiocarbamate (APDC) in aqueous buffer with up to 10.3-fold luminescence enhancement and limits of detection in the submicromolar range. Moreover, the probe has the capacity to detect dithiocarbamates in water and drink samples as well as in the presence of living cells. Importantly, this probe is robust to potential interferent including other coordinative thiols and histidine. This work serves as a good starting point for developing a single molecule-based sensing system for dithiocarbamates, and opens the door for developing new imaging probe for dithiocarbamates.

AB - Dithiocarbamate bioactive compounds are extensively used in agriculture and medicine, but traditional methods for the detection of dithiocarbamates are limited by complicated sensing systems and incompatibility with living systems. In this work, we developed an iridium(III) solvento complex (1) for the luminogenic detection of dithiocarbamates. The probe can sensitively detect a range of dithiocarbamates including sodium diethyldithiocarbamate (NDDC), sodium dimethyldithiocarbamate (SDDC) and ammonium pyrrolidinedithiocarbamate (APDC) in aqueous buffer with up to 10.3-fold luminescence enhancement and limits of detection in the submicromolar range. Moreover, the probe has the capacity to detect dithiocarbamates in water and drink samples as well as in the presence of living cells. Importantly, this probe is robust to potential interferent including other coordinative thiols and histidine. This work serves as a good starting point for developing a single molecule-based sensing system for dithiocarbamates, and opens the door for developing new imaging probe for dithiocarbamates.

KW - Cell imaging

KW - Dithiocarbamates

KW - Iridium(III) solvento complex

KW - Luminogenic detection

KW - Real samples

UR - http://www.scopus.com/inward/record.url?scp=85144446512&partnerID=8YFLogxK

U2 - 10.1016/j.snb.2022.133133

DO - 10.1016/j.snb.2022.133133

M3 - Journal article

AN - SCOPUS:85144446512

SN - 0925-4005

VL - 378

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

M1 - 133133

ER -

A labile iridium(III) complex-based luminogenic probe for the ratiometric detection of dithiocarbamate compounds in living system

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