A label-free oligonucleotide-based “OR” logic gate using an Ir(III) complex as a luminescent switch-on probe

Dik Lung Ma; Modi Wang; Wanhe Wang; Lihua Lu; David Hui-Min Wang; Chung-Hang Leung

A label-free oligonucleotide-based “OR” logic gate using an Ir(III) complex as a luminescent switch-on probe

Dik Lung Ma, Modi Wang, Wanhe Wang, Lihua Lu, David Hui-Min Wang, Chung-Hang Leung

Research output: Contribution to journal › Journal article › peer-review

Abstract

We have synthesized a luminescent iridium(III) complex and investigated its ability to act as a luminescent dual G-quadruplex and i-motif probe. Based on its selectivity towards both G-quadruplex and i-motif DNA, we have developed a label-free oligonucleotide-based “OR” logic gate by using the target-induced conformational transitions of cytosine- or guanine-rich oligonucleotides into i-motif and G-quadruplex structures in the presence of H+ and K+ ions, respectively, as chemical inputs.

Original language	English
Article number	180
Journal	Science Letters
Volume	4
Publication status	Published - Feb 2015

User-Defined Keywords

Iridium(III) complex
Logic gate
G-quadruplex
i-motif

Cite this

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title = "A label-free oligonucleotide-based “OR” logic gate using an Ir(III) complex as a luminescent switch-on probe",

abstract = "We have synthesized a luminescent iridium(III) complex and investigated its ability to act as a luminescent dual G-quadruplex and i-motif probe. Based on its selectivity towards both G-quadruplex and i-motif DNA, we have developed a label-free oligonucleotide-based “OR” logic gate by using the target-induced conformational transitions of cytosine- or guanine-rich oligonucleotides into i-motif and G-quadruplex structures in the presence of H+ and K+ ions, respectively, as chemical inputs.",

keywords = "Iridium(III) complex, Logic gate, G-quadruplex, i-motif",

author = "Ma, {Dik Lung} and Modi Wang and Wanhe Wang and Lihua Lu and Wang, {David Hui-Min} and Chung-Hang Leung",

year = "2015",

month = feb,

language = "English",

volume = "4",

journal = "Science Letters",

issn = "2454-7239",

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TY - JOUR

T1 - A label-free oligonucleotide-based “OR” logic gate using an Ir(III) complex as a luminescent switch-on probe

AU - Ma, Dik Lung

AU - Wang, Modi

AU - Wang, Wanhe

AU - Lu, Lihua

AU - Wang, David Hui-Min

AU - Leung, Chung-Hang

PY - 2015/2

Y1 - 2015/2

N2 - We have synthesized a luminescent iridium(III) complex and investigated its ability to act as a luminescent dual G-quadruplex and i-motif probe. Based on its selectivity towards both G-quadruplex and i-motif DNA, we have developed a label-free oligonucleotide-based “OR” logic gate by using the target-induced conformational transitions of cytosine- or guanine-rich oligonucleotides into i-motif and G-quadruplex structures in the presence of H+ and K+ ions, respectively, as chemical inputs.

AB - We have synthesized a luminescent iridium(III) complex and investigated its ability to act as a luminescent dual G-quadruplex and i-motif probe. Based on its selectivity towards both G-quadruplex and i-motif DNA, we have developed a label-free oligonucleotide-based “OR” logic gate by using the target-induced conformational transitions of cytosine- or guanine-rich oligonucleotides into i-motif and G-quadruplex structures in the presence of H+ and K+ ions, respectively, as chemical inputs.

KW - Iridium(III) complex

KW - Logic gate

KW - G-quadruplex

KW - i-motif

UR - http://www.cognizure.com/scilett.aspx?p=200638775

M3 - Journal article

SN - 2454-7239

VL - 4

JO - Science Letters

JF - Science Letters

M1 - 180

ER -

A label-free oligonucleotide-based “OR” logic gate using an Ir(III) complex as a luminescent switch-on probe

Abstract

User-Defined Keywords

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