A label-free oligonucleotide-based “OR” logic gate using an Ir(III) complex as a luminescent switch-on probe

Dik Lung Ma, Modi Wang, Wanhe Wang, Lihua Lu, David Hui-Min Wang, Chung-Hang Leung

Research output: Contribution to journalArticle

Abstract

We have synthesized a luminescent iridium(III) complex and investigated its ability to act as a luminescent dual G-quadruplex and i-motif probe. Based on its selectivity towards both G-quadruplex and i-motif DNA, we have developed a label-free oligonucleotide-based “OR” logic gate by using the target-induced conformational transitions of cytosine- or guanine-rich oligonucleotides into i-motif and G-quadruplex structures in the presence of H+ and K+ ions, respectively, as chemical inputs.
Original languageEnglish
Article number4491
JournalScience Letters
Volume4
Publication statusPublished - Feb 2015

User-Defined Keywords

  • Iridium(III) complex
  • Logic gate
  • G-quadruplex
  • i-motif

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