@article{64d9d83da6c640b28f30224ccfb235f5,
title = "A Label-Free Luminescent Switch-On Assay for ATP Using a G-Quadruplex-Selective Iridium(III) Complex",
abstract = "We report herein the G-quadruplex-selective property of a luminescent cyclometallated iridium(III) complex for the detection of adenosine-5′-triphosphate (ATP) in aqueous solution. The ATP-binding aptamer was employed as the ATP recognition unit, while the iridium(III) complex was used to monitor the formation of the G-quadruplex structure induced by ATP. The sensitivity and fold enhancement of the assay were higher than those of the previously reported assay using the organic dye crystal violet as a fluorescent probe. This label-free luminescent switch-on assay exhibits high sensitivity and selectivity towards ATP with a limit of detection of 2.5 μM.",
author = "Leung, {Ka Ho} and Lihua Lu and Modi Wang and Mak, {Tsun Yin} and Chan, {Daniel Shiu Hin} and Tang, {Fung Kit} and Leung, {Chung Hang} and Kwan, {Hiu Yee} and Zhiling YU and MA, {Edmond Dik Lung}",
note = "This work is supported by Hong Kong Baptist University (FRG2/11-12/009, FRG2/12-13/021), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Health and Medical Research Fund (HMRF/11101212), the Research Grants Council (HKBU/201811 and HKBU/204612), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), the Science and Technology Development Fund, Macao SAR (001/2012/A) and the University of Macau (MYRG091(Y2-L2)-ICMS12-LCH and MYRG121(Y2-L2)-ICMS12-LCH). ",
year = "2013",
month = oct,
day = "25",
doi = "10.1371/journal.pone.0077021",
language = "English",
volume = "8",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",
}