@article{dc34196724954ff29ddaac4fceaffae7,
title = "A label-free G-quadruplex-based mercury detection assay employing the exonuclease III-mediated cleavage of T-Hg2+-T mismatched DNA",
abstract = "We report herein the use of an exonuclease III and G-quadruplex probe to construct a G-quadruplex-based luminescence detection platform for Hg2+. Unlike common DNA-based Hg2+ detection methods, when using the dsDNA probe to monitor the hairpin formation, the intercalation of the dsDNA probe may be influenced by the distortion of dsDNA. This 'mix-and-detect' methodology utilized the G-quadruplex probe as the signal transducer and is simple, rapid, convenient to use and can detect down to 20 nM of Hg2+.",
keywords = "exonuclease III, G-quadruplex, iridium(III), mercury(II) ion",
author = "Wanhe Wang and Kang, \{Tian Shu\} and Chan, \{Philip Wai Hong\} and Lu, \{Jin Jian\} and Chen, \{Xiu Ping\} and Leung, \{Chung Hang\} and Ma, \{Dik Lung\}",
note = "This work is supported by Hong Kong Baptist University(FRG2/14-15/004), the Health and Medical Research Fund (HMRF/13121482 and HMRF/14130522), the Research Grants Council (HKBU/201811, HKBU/204612 and HKBU/201913), the French National Research Agency/Research Grants Council Joint Research Scheme (A-HKBU201/12), State Key Laboratory of Environmental and Biological Analysis Research Grant (SKLP-14-15-P001),National Natural Science Foundation of China (21575121), Guangdong Province Natural Science Foundation (2015A030313816), Hong Kong Baptist University Century Club Sponsorship Scheme 2015, Interdisciplinary Research Matching Scheme (RC-IRMS/14-15/06), the State Key Laboratory of Synthetic Chemistry, the Science and Technology Development Fund, Macao SAR (098/2014/A2 and 007/2014/AMJ), the University of Macau (MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM and MRG023/LCH/2013/ICMS).",
year = "2015",
month = nov,
day = "17",
doi = "10.1088/1468-6996/16/6/065004",
language = "English",
volume = "16",
journal = "Science and Technology of Advanced Materials",
issn = "1468-6996",
publisher = "Taylor and Francis Ltd.",
number = "6",
}