A highly selective g-quadruplex-based luminescent switch-on probe for the detection of gene deletion

Hong Zhang He; Daniel Shiu Hin Chan; Chung Hang Leung; Dik Lung Ma

doi:10.1039/c2cc32253f

A highly selective g-quadruplex-based luminescent switch-on probe for the detection of gene deletion

Hong Zhang He
, Daniel Shiu Hin Chan
, Chung Hang Leung
, Dik Lung Ma^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

94 Citations (Scopus)

Abstract

A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.

Original language	English
Pages (from-to)	9462-9464
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	76
DOIs	https://doi.org/10.1039/c2cc32253f
Publication status	Published - 28 Aug 2012

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title = "A highly selective g-quadruplex-based luminescent switch-on probe for the detection of gene deletion",

abstract = "A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.",

author = "He, \{Hong Zhang\} and Chan, \{Daniel Shiu Hin\} and Leung, \{Chung Hang\} and Ma, \{Dik Lung\}",

note = "This work is supported by Hong Kong Baptist University (FRG2/10-11/008 and FRG2/11-12/009), Environment and Conservation Fund (ECF Project 3/2010), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Research Fund for the Control of Infectious Diseases (RFCID/11101212), the Research Grants Council (HKBU/201811), the University of Macau (Start-up Research Grant to C.-H. Leung), MYRG091(Y1-L2)-ICMS12-LCH and MYRG121(Y1-L3)-ICMS12-LCH).",

year = "2012",

month = aug,

day = "28",

doi = "10.1039/c2cc32253f",

language = "English",

volume = "48",

pages = "9462--9464",

journal = "Chemical Communications",

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T1 - A highly selective g-quadruplex-based luminescent switch-on probe for the detection of gene deletion

AU - He, Hong Zhang

AU - Chan, Daniel Shiu Hin

AU - Leung, Chung Hang

AU - Ma, Dik Lung

N1 - This work is supported by Hong Kong Baptist University (FRG2/10-11/008 and FRG2/11-12/009), Environment and Conservation Fund (ECF Project 3/2010), Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU), the Research Fund for the Control of Infectious Diseases (RFCID/11101212), the Research Grants Council (HKBU/201811), the University of Macau (Start-up Research Grant to C.-H. Leung), MYRG091(Y1-L2)-ICMS12-LCH and MYRG121(Y1-L3)-ICMS12-LCH).

PY - 2012/8/28

Y1 - 2012/8/28

N2 - A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.

AB - A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.

UR - https://www.scopus.com/pages/publications/84865693386

U2 - 10.1039/c2cc32253f

DO - 10.1039/c2cc32253f

M3 - Journal article

C2 - 22692458

AN - SCOPUS:84865693386

SN - 1359-7345

VL - 48

SP - 9462

EP - 9464

JO - Chemical Communications

JF - Chemical Communications

IS - 76

ER -

A highly selective g-quadruplex-based luminescent switch-on probe for the detection of gene deletion

Abstract

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