A highly selective g-quadruplex-based luminescent switch-on probe for the detection of gene deletion

Hong Zhang He; Daniel Shiu Hin Chan; Chung Hang Leung; Edmond Dik Lung MA

doi:10.1039/c2cc32253f

A highly selective g-quadruplex-based luminescent switch-on probe for the detection of gene deletion

Hong Zhang He, Daniel Shiu Hin Chan, Chung Hang Leung, Edmond Dik Lung MA^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

91 Citations (Scopus)

Abstract

A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.

Original language	English
Pages (from-to)	9462-9464
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	76
DOIs	https://doi.org/10.1039/c2cc32253f
Publication status	Published - 28 Aug 2012

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc32253f

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abstract = "A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.",

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AB - A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.

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A highly selective g-quadruplex-based luminescent switch-on probe for the detection of gene deletion

Abstract

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