Abstract
A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.
Original language | English |
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Pages (from-to) | 9462-9464 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 48 |
Issue number | 76 |
DOIs | |
Publication status | Published - 28 Aug 2012 |
Scopus Subject Areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry