A highly selective g-quadruplex-based luminescent switch-on probe for the detection of gene deletion

Hong Zhang He, Daniel Shiu Hin Chan, Chung Hang Leung, Dik Lung Ma*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

93 Citations (Scopus)

Abstract

A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.

Original languageEnglish
Pages (from-to)9462-9464
Number of pages3
JournalChemical Communications
Volume48
Issue number76
DOIs
Publication statusPublished - 28 Aug 2012

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