A highly selective g-quadruplex-based luminescent switch-on probe for the detection of gene deletion

Hong Zhang He, Daniel Shiu Hin Chan, Chung Hang Leung, Edmond Dik Lung MA*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)

Abstract

A G-quadruplex-based switch-on luminescence assay has been developed for the detection of gene deletion using a cyclometallated iridium(III) complex as a G-quadruplex-selective probe. Upon hybridization with the target DNA, the two split G-quadruplex-forming sequences assemble into a split G-quadruplex, which greatly enhances the luminescence emission of the iridium(III) probe. The assay is simple and highly selective.

Original languageEnglish
Pages (from-to)9462-9464
Number of pages3
JournalChemical Communications
Volume48
Issue number76
DOIs
Publication statusPublished - 28 Aug 2012

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'A highly selective g-quadruplex-based luminescent switch-on probe for the detection of gene deletion'. Together they form a unique fingerprint.

Cite this