A high-throughput detection method for hepatitis B virus mutations in the Chinese population

C. C. Lau, W. Y. Ha, Patrick Y K YUE, S. H. Chui, A. K. K. Chui, Ricky N S WONG*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

1. Arrayed primer extension (APEX) has been successfully developed as a high-throughput method for single nucleotide polymorphisms (SNPs) present in the hepatitis B virus (HBV) genome.
2. Co-existence of wild-type and mutant genotypes in one SNP was successfully identified by APEX, which was not identified by conventional DNA sequencing.
3. Thirty-three patients were involved in this study; APEX results showed A1762T and G1764A double mutations and G1896A mutation are the most prevalent SNPs present in HBV genomes.
4. APEX can be developed as a SNP screening tool to monitor other infectious agents.
Original languageEnglish
Pages (from-to)S4-S7
Number of pages4
JournalHong Kong Medical Journal
Volume14
Issue number5, Suppl 5
Publication statusPublished - Oct 2008

Scopus Subject Areas

  • Medicine(all)

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