A glucose selective electrode based on calix[6]arene and application in human serum assay

Wing Hong CHAN*, Yee Ling Wong-Leung, Tse Fai Lai, Ruo Yuan

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

4 Citations (Scopus)

Abstract

Plasticized ploy(vinyl chloride) (PVC) membranes incorporating dealkylcalix[6]arene as a sensory material were developed for the determination of glucose after its in situ derivatization with a lipophilic Girard's P' reagent. In a TRIS-HCl buffer at pH 9.0, the electrode exhibits a near Nernstian response in the range 1.0 x 10-4 - 0.01 mol 1-1 glucose with a slope of 45.5 mV per concentration decade. The electrode has a fast response time and a long working lifetime. The selectivity of this electrode method allow its application to the assay of glucose concentration in human blood samples.

Original languageEnglish
Pages (from-to)45-59
Number of pages15
JournalAnalytical Letters
Volume30
Issue number1
DOIs
Publication statusPublished - 1997

Scopus Subject Areas

  • Analytical Chemistry
  • Biochemistry
  • Spectroscopy
  • Clinical Biochemistry
  • Biochemistry, medical
  • Electrochemistry

User-Defined Keywords

  • Calixarene
  • Girard's type reagents
  • Glucose determination
  • Host-guest interaction
  • Ion-selective electrode

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