Abstract
A cyclometallated Ir(III) complex was synthesised and evaluated for the ability to act as a luminescent G-triplex probe. The iridium(III) complex 1 [Ir(phq)2(2,9-dmphen)]PF6 (where phq = 2-phenylquinoline; 2,9-dmphen = 2,9-dimethyl-1,10-phenanthroline) exhibited high luminescence for G-triplex DNA over dsDNA and ssDNA, and was employed to construct a label-free G-triplex-based assay for mung bean nuclease activity in aqueous solution. This method was highly sensitive and selective for MB nuclease activity over other DNA-modifying enzymes.
Original language | English |
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Pages (from-to) | 348-352 |
Number of pages | 5 |
Journal | Journal of Materials Chemistry B |
Volume | 3 |
Issue number | 3 |
Early online date | 27 Nov 2014 |
DOIs | |
Publication status | Published - 21 Jan 2015 |
Scopus Subject Areas
- Chemistry(all)
- Biomedical Engineering
- Materials Science(all)