A G-pentaplex-based assay for Cs+ ions in aqueous solution using a luminescent Ir(III) complex

Sheng Lin, Chao Yang, Zhifeng Mao, Bingyong He, Yi Tao Wang, Chung Hang Leung*, Edmond Dik Lung MA

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

A series of 5 randomly designed in-house cyclometalated Ir(III) complexes were examined for their application in G-pentaplex probes and the "proof-of-principle" concept in G-pentaplex-based Cs+ ions detection. The G-pentaplex-forming sequence (DNA1, 5'-T(iG)4T-3', where iG=isoguanine) is present in single strand DNA form ab initio, however, the addition of Cs+ ions lead to formation of the intermolecular G-pentaplex structure which is identified by the novel Ir(III) complex 1 afterward and produce an enhanced luminescence signal for Cs+ ions monitoring. To the best of our knowledge, this is the first G-pentaplex probe and also the first G-pentaplex-based label-free detection platform for Cs+ ions reported in the literature. The monitoring of spiked Cs+ ions in natural water samples demonstrates the potential application and technical sound of this "proof-of-principle" concept sensing platform.

Original languageEnglish
Pages (from-to)609-612
Number of pages4
JournalBiosensors and Bioelectronics
Volume77
DOIs
Publication statusPublished - 15 Mar 2016

Scopus Subject Areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

User-Defined Keywords

  • Cs
  • G-pentaplex
  • Iridium(III) complex
  • Label-free detection

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