A FRET fluorescent chemosensor SPAQ for Zn2+ based on a dyad bearing spiropyran and 8-aminoquinoline unit

Jian Fa Zhu, Han Yuan, Wing Hong CHAN*, Albert W M LEE

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

A novel FRET fluorescent sensor SPAQ containing 8-aminoquinoline (donor) and spiropyran derivative (acceptor) was designed and synthesized for detecting Zn2+. The probe successfully exhibited a fluorescence turn on and ratiometric response for Zn2+ in ethanol solution with high selectivity. Upon excitation at 370 nm, the modulation of the emission intensity of SPAQ at 645 and 470 nm was achieved in the presence of Zn2+ by fluorescent resonance energy transfer (FRET) and chelation-enhanced fluorescence (CHEF) effects.

Original languageEnglish
Pages (from-to)3550-3554
Number of pages5
JournalTetrahedron Letters
Volume51
Issue number27
DOIs
Publication statusPublished - 7 Jul 2010

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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