A fluorescent probe for the discrimination of oxidation states of palladium

Lijun Jiang; Ho Nam Mak; Edward R.H. Walter; Wing Tak Wong; Ka Leung Wong; Nicholas J. Long

doi:10.1039/d1sc01616d

A fluorescent probe for the discrimination of oxidation states of palladium

Lijun Jiang, Ho Nam Mak, Edward R.H. Walter, Wing Tak Wong^*, Ka Leung Wong^*, Nicholas J. Long^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

11 Citations (Scopus)

Abstract

Palladium-based catalysts are widely used in pharmaceutical industries, which can sometimes cause palladium contamination in pharmaceutical drug manufacture. It is important to separately quantify the different oxidation states of palladium (Pd⁰and Pd²⁺) in pharmaceuticals as they react with scavengers differently. Although palladium sensors have been under intense investigation, oxidation state differentiators are very rare. Here, we report a simple porphyrin-coumarin conjugate,PPIX-L2, that can selectively discriminate between the oxidation states of palladium. The reaction ofPPIX-L2with Pd⁰showed a 24-fold fluorescence increase of the coumarin emission, meanwhile, the presence of Pd²⁺led to a 98% quenching of the porphyrin emission. Fluorescent responses ofPPIX-L2towards Pd⁰and Pd²⁺are specific, and its sensitivity towards both palladium species is significantly increased with a detection limit of 75 nM and 382 nM for Pd⁰and Pd²⁺respectively.

Original language	English
Pages (from-to)	9977-9982
Number of pages	6
Journal	Chemical Science
Volume	12
Issue number	29
Early online date	24 Jun 2021
DOIs	https://doi.org/10.1039/d1sc01616d
Publication status	Published - 7 Aug 2021

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Chemistry(all)

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@article{3cd2c18766d248378cc877bf7dd9b1d1,

title = "A fluorescent probe for the discrimination of oxidation states of palladium",

abstract = "Palladium-based catalysts are widely used in pharmaceutical industries, which can sometimes cause palladium contamination in pharmaceutical drug manufacture. It is important to separately quantify the different oxidation states of palladium (Pd0and Pd2+) in pharmaceuticals as they react with scavengers differently. Although palladium sensors have been under intense investigation, oxidation state differentiators are very rare. Here, we report a simple porphyrin-coumarin conjugate,PPIX-L2, that can selectively discriminate between the oxidation states of palladium. The reaction ofPPIX-L2with Pd0showed a 24-fold fluorescence increase of the coumarin emission, meanwhile, the presence of Pd2+led to a 98% quenching of the porphyrin emission. Fluorescent responses ofPPIX-L2towards Pd0and Pd2+are specific, and its sensitivity towards both palladium species is significantly increased with a detection limit of 75 nM and 382 nM for Pd0and Pd2+respectively.",

author = "Lijun Jiang and Mak, {Ho Nam} and Walter, {Edward R.H.} and Wong, {Wing Tak} and Wong, {Ka Leung} and Long, {Nicholas J.}",

note = "Funding Information: N. J. L. gratefully acknowledges the support of a Royal Society Wolfson Research Merit Award. K.-L. W. acknowledges the support from the Dr Mok Man Huang Endowed Professorship in HKBU Chemistry. We thank Dr P.-K. So (PolyU University Research Facility in Life Science) for technical assistance in MALDI-TOF mass spectrum. This work was supported by grants from Hong Kong Research Grant Council (HKBU 12300019). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",

year = "2021",

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doi = "10.1039/d1sc01616d",

language = "English",

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journal = "Chemical Science",

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T1 - A fluorescent probe for the discrimination of oxidation states of palladium

AU - Jiang, Lijun

AU - Mak, Ho Nam

AU - Walter, Edward R.H.

AU - Wong, Wing Tak

AU - Wong, Ka Leung

AU - Long, Nicholas J.

N1 - Funding Information: N. J. L. gratefully acknowledges the support of a Royal Society Wolfson Research Merit Award. K.-L. W. acknowledges the support from the Dr Mok Man Huang Endowed Professorship in HKBU Chemistry. We thank Dr P.-K. So (PolyU University Research Facility in Life Science) for technical assistance in MALDI-TOF mass spectrum. This work was supported by grants from Hong Kong Research Grant Council (HKBU 12300019). Publisher Copyright: © The Royal Society of Chemistry 2021.

PY - 2021/8/7

Y1 - 2021/8/7

N2 - Palladium-based catalysts are widely used in pharmaceutical industries, which can sometimes cause palladium contamination in pharmaceutical drug manufacture. It is important to separately quantify the different oxidation states of palladium (Pd0and Pd2+) in pharmaceuticals as they react with scavengers differently. Although palladium sensors have been under intense investigation, oxidation state differentiators are very rare. Here, we report a simple porphyrin-coumarin conjugate,PPIX-L2, that can selectively discriminate between the oxidation states of palladium. The reaction ofPPIX-L2with Pd0showed a 24-fold fluorescence increase of the coumarin emission, meanwhile, the presence of Pd2+led to a 98% quenching of the porphyrin emission. Fluorescent responses ofPPIX-L2towards Pd0and Pd2+are specific, and its sensitivity towards both palladium species is significantly increased with a detection limit of 75 nM and 382 nM for Pd0and Pd2+respectively.

AB - Palladium-based catalysts are widely used in pharmaceutical industries, which can sometimes cause palladium contamination in pharmaceutical drug manufacture. It is important to separately quantify the different oxidation states of palladium (Pd0and Pd2+) in pharmaceuticals as they react with scavengers differently. Although palladium sensors have been under intense investigation, oxidation state differentiators are very rare. Here, we report a simple porphyrin-coumarin conjugate,PPIX-L2, that can selectively discriminate between the oxidation states of palladium. The reaction ofPPIX-L2with Pd0showed a 24-fold fluorescence increase of the coumarin emission, meanwhile, the presence of Pd2+led to a 98% quenching of the porphyrin emission. Fluorescent responses ofPPIX-L2towards Pd0and Pd2+are specific, and its sensitivity towards both palladium species is significantly increased with a detection limit of 75 nM and 382 nM for Pd0and Pd2+respectively.

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U2 - 10.1039/d1sc01616d

DO - 10.1039/d1sc01616d

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SN - 2041-6520

VL - 12

SP - 9977

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JO - Chemical Science

JF - Chemical Science

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ER -

A fluorescent probe for the discrimination of oxidation states of palladium

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